| Beyond blood lipids: phytosterols, statins and omega-3 polyunsaturated fatty acid therapy for hyperlipidemia. | |
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MedLine Citation:
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PMID: 19733044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phytosterols and omega-3 fatty acids are natural compounds with potential cardiovascular benefits. Phytosterols inhibit cholesterol absorption, thereby reducing total- and LDL cholesterol. A number of clinical trials have established that the consumption of 1.5-2.0 g/day of phytosterols can result in a 10-15% reduction in LDL cholesterol in as short as a 3-week period in hyperlipidemic populations. Added benefits of phytosterol consumption have been demonstrated in people who are already on lipid-lowering medications (statin drugs). On the other hand, omega-3 fatty acid supplementation has been associated with significant hypotriglyceridemic effects with concurrent modifications of other risk factors associated with cardiovascular disease, including platelet function and pro-inflammatory mediators. Recent studies have provided evidence that the combination of phytosterols and omega-3 fatty acids may reduce cardiovascular risk in a complementary and synergistic way. This article reviews the health benefits of phytosterols and omega-3 fatty acids, alone or in combination with statins, for the treatment/management of hyperlipidemia, with particular emphasis on the mechanisms involved. |
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Authors:
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Michelle A Micallef; Manohar L Garg |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-09-03 |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 20 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-16 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 927-39 Citation Subset: IM |
Affiliation:
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Nutraceuticals Research Group, School of Biomedical Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticholesteremic Agents
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therapeutic use Cardiovascular Diseases / drug therapy, etiology Cholesterol, LDL / drug effects Diet Eicosanoids / biosynthesis Fatty Acids, Omega-3 / therapeutic use* Food, Fortified Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hyperlipidemias / drug therapy* Intestinal Absorption Lipids / blood Micelles Phytosterols / therapeutic use* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, LDL; 0/Eicosanoids; 0/Fatty Acids, Omega-3; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipids; 0/Micelles; 0/Phytosterols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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