| Beyond Zoster: Sensory and Immune Changes in Zoster-affected Dermatomes. | |
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MedLine Citation:
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PMID: 22294236 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Neuroepidermal tropism of varicella-zoster virus accounts for cutaneous and nerve lesions following herpes zoster. Skin lesions heal in a few weeks and may or may not leave visible scars. Nerve lesions involve peripheral sensory fibres, sometimes causing permanent damage that results in partial denervation of the affected dermatome. The effects of the nerve injury involve the sensibility function, thus causing neuralgia, itch, allodynia, hypo- or anaesthesia, as well as the immune function that is related to neuropeptide release, thus altering immune control in the affected dermatome. The neuro-immune destabilization in the zoster-infected site paves the way for the onset of many and various immunity-related disorders along the affected dermatome. |
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Authors:
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Vincenzo Ruocco; Sonia Sangiuliano; Giampiero Brunetti; Eleonora Ruocco |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-1 |
Journal Detail:
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Title: Acta dermato-venereologica Volume: - ISSN: 1651-2057 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatology, 2nd University of Naples via Sergio Pansini, 5, I-80131 Napoli, Italy. E-mail: vincenzo.ruocco@unina2.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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