| Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection. | |
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MedLine Citation:
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PMID: 17560276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As the primary effector of immunoglobulin somatic hypermutation (SHM) and class switch recombination (CSR), activation-induced cytidine deaminase (AID) serves an important function in the adaptive immune response. Recent advances have demonstrated that AID and a group of closely related cytidine deaminases, the APOBEC3 proteins, also act in the innate host response to viral infection. Antiviral activity was first attributed to APOBEC3G as a potent inhibitor of HIV. It is now apparent that the targets of the APOBEC3 proteins extend beyond HIV, with family members acting against a wide variety of viruses as well as host-encoded retrotransposable genetic elements. Although it appears to function through a different mechanism, AID also possesses antiviral properties. Independent of its antibody diversification functions, AID protects against transformation by Abelson murine leukemia virus (Ab-MLV), an oncogenic retrovirus. Additionally, AID has been implicated in the host response to other pathogenic viruses. These emerging roles for the AID/APOBEC cytidine deaminases in viral infection suggest an intriguing evolutionary connection of innate and adaptive immune mechanisms. |
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Authors:
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Brad R Rosenberg; F Nina Papavasiliou |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Advances in immunology Volume: 94 ISSN: 0065-2776 ISO Abbreviation: Adv. Immunol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-06-11 Completed Date: 2007-09-12 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0370425 Medline TA: Adv Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 215-44 Citation Subset: IM |
Affiliation:
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Laboratory of Lymphocyte Biology, The Rockefeller University, New York, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytidine Deaminase / immunology* HIV Infections / immunology Humans Immunoglobulin Class Switching Somatic Hypermutation, Immunoglobulin Virus Diseases / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AI071029/AI/NIAID NIH HHS; GM07739/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.5.4.-/AICDA (activation-induced cytidine deaminase); EC 3.5.4.5/Cytidine Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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