Document Detail


Between promiscuity and specificity: Novel roles of EF-hand calcium sensors in neuronal Ca(2+) signalling.
MedLine Citation:
PMID:  21722133     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In recent years substantial progress has been made towards an understanding of the physiological function of EF-hand calcium sensor proteins of the Calmodulin superfamily in neurons. This deeper appreciation is based on the identification of novel target interactions, structural studies and the discovery of novel signalling mechanisms in protein trafficking and synaptic plasticity, in which CaM-like sensor proteins appear to play a role. However, not all interactions are of plausible physiological relevance and in many cases it is not yet clear how the CaM signaling network relates to the proposed function of other EF-hand sensors. In this review we will summarize these findings and address some of the open questions on the functional role of EF-hand calcium binding proteins in neurons.
Authors:
Marina Mikhaylova; Johannes Hradsky; Michael R Kreutz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-1
Journal Detail:
Title:  Journal of neurochemistry     Volume:  -     ISSN:  1471-4159     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Journal of Neurochemistry © 2011 International Society for Neurochemistry.
Affiliation:
PG Neuroplasticity, Leibniz-Institute for Neurobiology, Magdeburg, Germany German Center for Neurodegenerative Diseases (DZNE), Location Magdeburg, Germany.
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