Document Detail

Between pregnancy biological variability of first trimester markers of Down syndrome: implications for screening in subsequent pregnancies.
MedLine Citation:
PMID:  11438946     Owner:  NLM     Status:  MEDLINE    
In a group of 149 women who had undergone routine first trimester screening using fetal nuchal translucency thickness (NT) and maternal serum free beta-hCG and pregnancy associated plasma protein-A (PAPP-A) in two consecutive pregnancies the within person between pregnancy biological variability of these markers has been assessed. For fetal NT there was no correlation between NT MoM in the first and second pregnancy (r=0.0800). For maternal serum free beta-hCG MoM a significant correlation was observed (r=0.4174) as was also found for PAPP-A MoM (r=0.3270). The implications for such between pregnancy marker association is that women who have an increased risk of Down syndrome in their first pregnancy are 1.5-2 times more likely to repeat this event in their next pregnancy. This observation may be useful in counselling women in the first trimester screening of a subsequent pregnancy.
K Spencer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  21     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-04     Completed Date:  2001-09-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  445-7     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Ltd.
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK.
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MeSH Terms
Biological Markers* / blood
Chorionic Gonadotropin, beta Subunit, Human / blood
Down Syndrome / blood,  diagnosis*,  ultrasonography
Genetic Counseling*
Genetic Testing*
Neck / embryology,  ultrasonography
Pregnancy Trimester, First / blood
Pregnancy-Associated Plasma Protein-A / metabolism
Prenatal Diagnosis*
Ultrasonography, Prenatal
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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