Document Detail

Between death and survival: retinoic acid in regulation of apoptosis.
MedLine Citation:
PMID:  20415582     Owner:  NLM     Status:  MEDLINE    
The vitamin A metabolite all-trans-retinoic acid (RA) regulates multiple biological processes by virtue of its ability to regulate gene expression. It thus plays critical roles in embryonic development and is involved in regulating growth, remodeling, and metabolic responses in adult tissues. RA can also suppress carcinoma cell growth and is currently used in treatment of some cancers. Growth inhibition by RA may be exerted by induction of differentiation, cell cycle arrest, or apoptosis, or by a combination of these activities. Paradoxically, in the context of some cells, RA not only fails to inhibit growth but, instead, enhances proliferation and survival. This review focuses on the involvement of RA in regulating apoptotic responses. It includes brief overviews of transcriptional signaling by RA and of apoptotic pathways, and then addresses available information on the mechanisms by which RA induces apoptosis or, conversely, inhibits cell death and enhances survival.
Noa Noy
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of nutrition     Volume:  30     ISSN:  1545-4312     ISO Abbreviation:  Annu. Rev. Nutr.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8209988     Medline TA:  Annu Rev Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-17     Citation Subset:  IM    
Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4965, USA.
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MeSH Terms
Antineoplastic Agents
Apoptosis / drug effects,  physiology*
Gene Expression Regulation / physiology*
Receptors, Retinoic Acid / physiology*
Signal Transduction / drug effects,  physiology
Tretinoin / physiology*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Receptors, Retinoic Acid; 302-79-4/Tretinoin

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