Document Detail


Better living through chemistry: does it still apply to patients after myocardial infarction?
MedLine Citation:
PMID:  12820824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sudden cardiac death is an elusive process that claims a significant number of lives annually in the United States. It is often associated with increased mortality within the first year after myocardial infarction, with the highest frequency occurring among patients with left ventricular dysfunction. Therefore, increasing survival rates in patients with a history of both disorders is an important goal of therapy. Recent trials suggested that an implantable cardioverter-defibrillator (ICD) in these patients may be superior to medical intervention in reducing the high mortality rate. Four major trials measured the benefits of an ICD for patients at risk for life-threatening ventricular arrhythmias. We assessed whether patients in these trials received adequate drug therapy as directed by American College of Cardiology-American Heart Association guidelines. One aim was to determine if medicated patients who served as controls in the trials were fairly represented. Furthermore, the need for improved overall guideline adherence was apparent.
Authors:
Thomas F Oppelt; Rodel V Bobadilla
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  23     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-24     Completed Date:  2003-10-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  816-22     Citation Subset:  IM    
Affiliation:
Department of Pharmacy Practice, College of Pharmacy, University of South Carolina 700 Sumter Street, University of South Carolina, Columbia, SC 29208, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use
Amiodarone / therapeutic use
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Cardiovascular Agents / therapeutic use*
Death, Sudden, Cardiac / prevention & control*
Defibrillators, Implantable*
Humans
Myocardial Infarction / complications*
Platelet Aggregation Inhibitors
Randomized Controlled Trials as Topic
Treatment Outcome
Ventricular Remodeling / drug effects*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Cardiovascular Agents; 0/Platelet Aggregation Inhibitors; 1951-25-3/Amiodarone
Comments/Corrections
Comment In:
Pharmacotherapy. 2004 Feb;24(2):298-305; discussion 305-6   [PMID:  14998229 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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