| Better Prognosis of Multiple Sclerosis in Patients Who Experienced a Full-Term Pregnancy. | |
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MedLine Citation:
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PMID: 22854684 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: We conducted a longitudinal prospective study to evaluate the long-term effect of pregnancy on the progression of multiple sclerosis (MS). Method: Parous female MS patients were extracted from the database of Isfahan Multiple Sclerosis Society (IMSS). Through comparing the annual relapsing rate during a mean of 4 years before pregnancy versus a mean of 6 years after delivery, MS progression influenced by the pregnancy was analyzed. Result: 102 female patients were included in our study. The mean annual relapsing rate 4 years prior to pregnancy was significantly higher than at the subsequent 6 years after delivery (1.06 vs. 0.45, p < 0.001). In addition, the annual relapsing rate in years prior to pregnancy was significantly higher than each trimester of gestation (p < 0.001). Furthermore, there was a 2.2-fold increased risk of having a relapse in individuals who had experienced more relapses prior to pregnancy, and a 0.8-fold decreased in the risk of having more relapses with older age at the onset of MS. Conclusion: Although the course of MS was deteriorated 3 months after delivery, it was not statistically significant comparing annual relapsing rates during the years prior to pregnancy. Moreover, the rate of disease progression slowed down in the 6-year period monitored after delivery. |
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Authors:
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Kiandokht Keyhanian; Vahid Davoudi; Masoud Etemadifar; Mohammad Amin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-31 |
Journal Detail:
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Title: European neurology Volume: 68 ISSN: 1421-9913 ISO Abbreviation: Eur. Neurol. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-8-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: - |
Other Details:
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Languages: ENG Pagination: 150-155 Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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