Document Detail


Betamethasone vs dexamethasone for the prevention of morbidity in very-low-birthweight neonates.
MedLine Citation:
PMID:  17826422     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to compare neonatal outcomes in very-low-birthweight infants who were exposed to antenatal betamethasone vs dexamethasone. STUDY DESIGN: We reviewed all inborn very-low-birthweight infants from January 1997 through February 2006. Maternal medical records were reviewed to determine the type of antenatal steroids that each patient received; neonatal outcomes were compared using chi-square and Student t tests. RESULTS: There were 334 very-low-birthweight infants who met the criteria for evaluation: 186 infants received betamethasone, and 148 infants received dexamethasone. There were no differences in race, gestational age at delivery, or mean birthweight between the 2 groups. There were significantly lower rates of respiratory distress syndrome and bronchopulmonary dysplasia in the betamethasone group, compared with the dexamethasone group. Other neonatal outcomes were similar in both groups. CONCLUSION: Antenatal betamethasone was associated with a significantly lower rate of pulmonary complications caused by prematurity, when compared with dexamethasone.
Authors:
Deborah M Feldman; Jeannine Carbone; Laura Belden; Adam F Borgida; Victor Herson
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  197     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-10     Completed Date:  2007-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  284.e1-4     Citation Subset:  AIM; IM    
Affiliation:
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Hartford Hospital, Hartford, CT, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Betamethasone / therapeutic use*
Bronchopulmonary Dysplasia / etiology,  prevention & control*
Dexamethasone / therapeutic use*
Female
Glucocorticoids / therapeutic use*
Humans
Infant, Newborn
Infant, Very Low Birth Weight*
Pregnancy
Premature Birth
Prenatal Exposure Delayed Effects
Respiratory Distress Syndrome, Newborn / etiology,  prevention & control*
Retrospective Studies
Chemical
Reg. No./Substance:
0/Glucocorticoids; 378-44-9/Betamethasone; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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