| Betamethasone valerate inhalation and exercise-induced asthma in adults. | |
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MedLine Citation:
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PMID: 338009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of regular inhalation of betamethasone valerate (800 microgram daily) on exercise-induced asthma has been studied in 18 adult patients. The active aerosol was compared with placebo in a double-blind cross-over study, each inhaler being used for four weeks. Exercise tests after each period of treatment were performed using a cycle ergometer, care being taken to match the oxygen uptake during exercise each time a patient was tested. Twelve patients experienced less exercise-induced fall in peak expiratory flow rate after the corticosteroid inhaler, while six did not. This effect appeared to be independent of any alteration in base-line lung function, suggesting that it was due primarily to diminution of bronchial hyperreactivity. It is suggested that this change may have been due to interference with the synthesis or release of mediator substances from mast cells. |
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Authors:
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J P Hartley; T J Charles; A Seaton |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of diseases of the chest Volume: 71 ISSN: 0007-0971 ISO Abbreviation: Br J Dis Chest Publication Date: 1977 Oct |
Date Detail:
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Created Date: 1978-02-18 Completed Date: 1978-02-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7511123 Medline TA: Br J Dis Chest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 253-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aerosols Asthma / drug therapy*, etiology, physiopathology Betamethasone / analogs & derivatives* Betamethasone 17-Valerate / therapeutic use* Clinical Trials as Topic Double-Blind Method Female Humans Male Peak Expiratory Flow Rate Physical Exertion Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 2152-44-5/Betamethasone 17-Valerate; 378-44-9/Betamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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