Document Detail

Betamethasone-induced hypokalemic periodic paralysis in pregnancy.
MedLine Citation:
PMID:  21252779     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: : Acute hypokalemic periodic paralysis may be induced by betamethasone injections during pregnancy.
CASE: : A healthy 23-year-old gravid woman at 32 weeks of gestation with preterm premature rupture of membranes received two doses of 12-mg intramuscular betamethasone 24 hours apart to accelerate fetal lung maturation. She developed significant proximal muscle weakness within 16 hours after the initial dose. Her serum potassium was 1.6 mEq/L. Oral and parenteral potassium replacement restored her neuromuscular function over several days. She delivered by repeat cesarean at 34 weeks of gestation without complications for her or the neonate.
CONCLUSION: : Hypokalemic periodic paralysis, a rare cause of weakness, may be induced by betamethasone injections during pregnancy and is reversible with low-risk interventions.
Corey M Teagarden; Carla W Picardo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  117     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  433-5     Citation Subset:  AIM; IM    
From the Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania; and St. Vincent Health System, Erie, Pennsylvania and the Department of Social Medicine at the University of North Carolina School of Medicine in Chapel Hill, North Carolina.
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