Document Detail

Betamethasone increases pulmonary compliance in part by surfactant-independent mechanisms in preterm rabbits.
MedLine Citation:
PMID:  3431959     Owner:  NLM     Status:  MEDLINE    
Antenatal exposure to corticosteroids is known to increase the pulmonary compliance of preterm animals. We wished to determine whether this was due solely to alteration in lung surfactant content. Rabbit does were injected with either vehicle alone or betamethasone on days 25 and 26 of gestation. Fetuses were delivered at 27 days and given either 50% lactated Ringer's or intratracheal natural surfactant prior to their first breath. Fetuses were mechanically ventilated at a tidal volume of 12 ml/kg for 60 min with periodic compliance measurements. Following ventilation an alveolar lavage was collected for phosphatidylcholine determination. Some fetuses did not undergo ventilation but had saline compliance studies instead. Fetuses given intratracheal surfactant had a higher dynamic compliance than fetuses exposed to antenatal corticosteroids (0.55 +/- 0.01 versus 0.48 +/- 0.02 ml/cm H2O/kg, respectively). Fetuses exposed to antenatal corticosteroids and given intratracheal surfactant had a dynamic compliance (0.66 +/- 0.02) that was greater than those exposed to either single therapy. This was found despite an alveolar surfactant content equal to that in fetuses receiving intratracheal surfactant alone. Saline compliance at birth was significantly greater for fetuses exposed antenatally to steroids. These data imply the existence of a nonsurfactant mechanism by which antenatal corticosteroids increase fetal pulmonary compliance.
J M Fiascone; H C Jacobs; F R Moya; M R Mercurio; D M Lima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  22     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-02-26     Completed Date:  1988-02-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  730-5     Citation Subset:  IM    
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510.
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MeSH Terms
Animals, Newborn
Betamethasone / pharmacology*
Lung Compliance / drug effects*
Pulmonary Surfactants / pharmacology,  physiology
Grant Support
Reg. No./Substance:
0/Pulmonary Surfactants; 378-44-9/Betamethasone

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