Document Detail

Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects.
MedLine Citation:
PMID:  12399266     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Betaine (trimethylglycine) is found in several tissues in humans. It is involved in homocysteine metabolism as an alternative methyl donor and is used in the treatment of homocystinuria in humans. In pigs, betaine decreases the amount of adipose tissue. OBJECTIVE: The aim of the study was to examine the effect of betaine supplementation on body weight, body composition, plasma homocysteine concentrations, blood pressure, and serum total and lipoprotein lipids. DESIGN: Forty-two obese, white subjects (14 men, 28 women) treated with a hypoenergetic diet were randomly assigned to a betaine-supplemented group (6 g/d) or a control group given placebo for 12 wk. The intervention period was preceded by a 4-wk run-in period with a euenergetic diet. RESULTS: Body weight, resting energy expenditure, and fat mass decreased significantly in both groups with no significant difference between the groups. Plasma homocysteine concentrations decreased in the betaine group ( +/- SD: 8.76 +/- 1.63 micro mol/L at 4 wk, 7.93 +/- 1.52 micro mol/L at 16 wk; P = 0.030 for the interaction of time and treatment). Diastolic blood pressure decreased without a significant difference between the groups. Serum total and LDL-cholesterol concentrations were higher in the betaine group than in the control group (P < 0.05). CONCLUSION: A hypoenergetic diet with betaine supplementation (6 g daily for 12 wk) decreased the plasma homocysteine concentration but did not affect body composition more than a hypoenergetic diet without betaine supplementation did.
Ursula Schwab; Anneli Törrönen; Leena Toppinen; Georg Alfthan; Markku Saarinen; Antti Aro; Matti Uusitupa
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  76     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-25     Completed Date:  2002-11-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  961-7     Citation Subset:  AIM; IM    
Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland.
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MeSH Terms
Betaine / blood,  pharmacology*
Blood Pressure / drug effects
Body Composition / drug effects*
Body Weight / drug effects*
Dietary Supplements
Energy Intake
Energy Metabolism / drug effects*
Folic Acid / blood
Homocystine / blood*
Lipoproteins / blood
Lipotropic Agents / blood,  pharmacology*
Middle Aged
Physical Exertion / drug effects
Reg. No./Substance:
0/Lipoproteins; 0/Lipotropic Agents; 107-43-7/Betaine; 462-10-2/Homocystine; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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