Document Detail

Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice.
MedLine Citation:
PMID:  18656477     Owner:  NLM     Status:  MEDLINE    
We employed transgenic mice overexpressing betacellulin (BTC) to study its effects in the gut. BTC stimulated crypt cell proliferation and markedly increased intestinal size, while the crypt-villus architecture was preserved. Introduction of a dominant negative epidermal growth factor receptor (EGFR) completely abolished the intestinal hyperplasia. BTC increased polyp multiplicity but did not change the mean size or the histological quality of intestinal polyps in Apc(+/Min) mice. Analysis of intact and cleaved caspase-3 levels indicated that BTC has anti-apoptotic effects in the intestinal epithelium. We conclude that increased BTC levels support the survival of nascent adenomas in Apc(+/Min) mice, resulting in a larger total polyp number at later stages.
Maik Dahlhoff; David Horst; Markus Gerhard; Frank T Kolligs; Eckhard Wolf; Marlon R Schneider
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Publication Detail:
Type:  Journal Article     Date:  2008-07-24
Journal Detail:
Title:  FEBS letters     Volume:  582     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-12     Completed Date:  2008-10-14     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2911-5     Citation Subset:  IM    
Institute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Feodor-Lynen-Strasse 25, Munich, Germany.
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MeSH Terms
Adenomatous Polyposis Coli / genetics*,  pathology
Adenomatous Polyposis Coli Protein / genetics
Cell Proliferation
Hyperplasia / genetics,  pathology
Intercellular Signaling Peptides and Proteins / genetics,  physiology*
Intestinal Mucosa / abnormalities,  metabolism,  pathology*
Intestinal Neoplasms / genetics*,  pathology
Mice, Transgenic
Organ Size / genetics
Receptor, Epidermal Growth Factor / genetics
Reg. No./Substance:
0/Adenomatous Polyposis Coli Protein; 0/Intercellular Signaling Peptides and Proteins; 0/betacellulin; EC, Epidermal Growth Factor

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