Document Detail


Beta-thalassemia: the Lebanese experience.
MedLine Citation:
PMID:  16898958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Beta-thalassemia is a hereditary anemia that is quite prevalent in Lebanon. Most patients with beta-Thalassemia are treated and followed up mostly at a multidisciplinary center, located in the suburban area of Beirut: the Chronic Care Center (CCC), operational since 1994. We will review the experience with beta-Thalassemia accumulated through this institution. Four hundred and twenty five patients, aged 2 to 68 years are followed up at the CCC. Sixty four percent have thalassemia major (TM) while 36% have thalassemia intermedia (TI). Lebanese patients with TM receive periodic packed red cell transfusions to maintain a pre-transfusional hemoglobin level of 10 gm/dl at all times and desferrioxamine is the standard iron chelator in use. Since 1994, 12 patients with TM have died from complications of their disease, with heart failure being responsible for the majority of deaths. The incidence of cardiac, endocrinologic, and infectious complications will be reviewed. Finally, both current and prospective preventive measures will be discussed, specifically educational campaigns and premarital screening. The effects of prevention are starting to show as the number of newly diagnosed disease is diminishing.
Authors:
A Inati; N Zeineh; H Isma'eel; S Koussa; W Gharzuddine; A Taher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  28     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-10     Completed Date:  2006-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  217-27     Citation Subset:  IM    
Affiliation:
Chronic Care Center, Baabda, Lebanon.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Child, Preschool
Erythrocyte Transfusion / adverse effects
Female
Humans
Infant
Infant, Newborn
Lebanon / epidemiology
Male
Middle Aged
beta-Thalassemia* / complications,  epidemiology,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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