Document Detail

Beta-melanocyte-stimulating hormone potently reduces appetite via the hypothalamus in chicks.
MedLine Citation:
PMID:  18088360     Owner:  NLM     Status:  MEDLINE    
The melanocortin system together with other appetite-related systems plays a significant role in appetite regulation. The appetite-related effects of one such melanocortin, beta-melanocyte-stimulating hormone (MSH), are well documented in rodents; however, its effects in the avian class are not thoroughly understood. Thus, we designed a study to determine the effects of i.c.v. beta-MSH injection on food and water intake, plasma corticosterone concentration, ingestive and non-ingestive behaviours, and hypothalamic neuronal activation using Cobb-500 chicks. Chicks responded to beta-MSH-treatment with a reduction in food and water intake; however when water intake was measured independently of food intake, it was not affected. beta-MSH-treated chicks also had increased plasma corticosterone concentrations and increased c-Fos reactivity in the periventricular, paraventricular and infundibular nuclei, and the ventromedial hypothalamus; however, the lateral hypothalamus was not affected. The effect on food intake is primary because behaviours that may be competitive with food intake were not increased in beta-MSH-treated chicks. Based on these results, we conclude that beta-MSH causes anorexigenic effects that are likely primarily mediated via stimulation of satiety-related hypothalamic nuclei in broiler-type chicks.
M L Smith; B Prall; W Nandar; M A Cline
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-12-14
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  20     ISSN:  1365-2826     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-30     Completed Date:  2008-04-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-6     Citation Subset:  IM    
Department of Cellular, Molecular, and Systemic Physiology, Southern Illinois University School of Medicine, Carbondale, IL, USA.
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MeSH Terms
Animals, Newborn*
Appetite / drug effects*
Corticosterone / blood
Drinking / drug effects
Eating / drug effects
Feeding Behavior / drug effects
Food Deprivation / physiology
Hypothalamus / drug effects*
Injections, Intraventricular
Osmolar Concentration
alpha-MSH / pharmacology
beta-MSH / administration & dosage,  pharmacology*
Reg. No./Substance:
0/beta-MSH; 50-22-6/Corticosterone; 581-05-5/alpha-MSH

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