Document Detail


Beta-lactam antibiotic decreases acquisition of and motivation to respond for cocaine, but not sweet food, in C57Bl/6 mice.
MedLine Citation:
PMID:  21543969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
No medication is approved to treat cocaine addiction, but mounting evidence suggests that glutamate-directed approaches may reduce cocaine dependence and relapse. We tested the hypotheses that the glutamate transporter subtype 1 activator, ceftriaxone, disrupts acquisition of cocaine self-administration, motivation to self-administer cocaine, and conditioned place preference in mice. Repeated ceftriaxone (200 mg/kg) reduced the ability of mice to acquire cocaine and the motivation to self-administer cocaine after successful acquisition without affecting acquisition of or motivation for sweet food. Repeated ceftriaxone had no effect on cocaine-conditioned place preference. These results suggest that a β-lactam antibiotic reduces the direct reinforcing strength of cocaine without producing nonspecific deficits in conditioned learning processes.
Authors:
Sara Jane Ward; Bruce A Rasmussen; Gladys Corley; Craig Henry; Jae K Kim; Ellen A Walker; Scott M Rawls
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  22     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-13     Completed Date:  2011-11-15     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  370-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / pharmacology*
Ceftriaxone / pharmacology
Cocaine / pharmacology*
Cocaine-Related Disorders / psychology*
Conditioning, Operant / drug effects*
Dose-Response Relationship, Drug
Excitatory Amino Acid Transporter 2 / metabolism
Food*
Male
Mice
Mice, Inbred C57BL
Motivation / drug effects*
Reinforcement (Psychology)
Reinforcement Schedule
Reward
Self Administration
beta-Lactams / pharmacology*
Grant Support
ID/Acronym/Agency:
P30 DA013429-13/DA/NIDA NIH HHS; RC1 DA028153/DA/NIDA NIH HHS; RC1 DA028153-01/DA/NIDA NIH HHS; RC1DA028153/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Excitatory Amino Acid Transporter 2; 0/Slc1a2 protein, mouse; 0/beta-Lactams; 75J73V1629/Ceftriaxone; I5Y540LHVR/Cocaine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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