| Beta-glucuronidase activity of Yoshida ascites hepatomas of different drug-sensitivity and its change after treatment of host rats with various anticancer agents. | |
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MedLine Citation:
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PMID: 57896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Change in beta-glucuronidase activity of six Yoshida ascites hepatomas was examined after treatment of host rats with one of 12 anticancer agents. The hepatomas, AH-66F, AH-130, AH-109A, AH-60C, and AH-44, in decreasing order showed more or less distinct increase in beta-glucuronidase activity after treatment of the rats with Nitromin, Endoxan, 864-T, Carbazilquinone, Mitomycin-C, Toyomycin, Daunomycin, Neocarzinostatin, vincristine sulfate, 5-fluorouracil, or cytosine arabinoside only when the cytological effect was positive. Moreover, degree of the increase was generally correlated with that of cytological effect. Bleomycin was ineffective either enzymically or cytologically. AH-66 was insensitive to any of the agents tested in increasing beta-glucuronidase activity and showed only a very slight cytological response to some of the agents. Acid deoxyribonuclease behaved like beta-glucuronidase but to a lesser extent. The above order of drug sensitivity of the hepatomas was not in parallel with that of normal beta-glucuronidase level, which also did not correlate with the life span of host rats. |
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Authors:
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I Abe; S Sato |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gann = Gan Volume: 67 ISSN: 0016-450X ISO Abbreviation: Gann Publication Date: 1976 Feb |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8214471 Medline TA: Gann Country: JAPAN |
Other Details:
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Languages: eng Pagination: 55-65 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / pharmacology* Bleomycin / pharmacology Carbazilquinone / pharmacology Carcinoma, Hepatocellular / enzymology* Chromomycins / pharmacology Cyclophosphamide / pharmacology Cytarabine / pharmacology Daunorubicin / pharmacology Deoxyribonucleases / metabolism Fluorouracil / pharmacology Glucuronidase / metabolism* Liver Neoplasms / enzymology* Male Mesylates / pharmacology* Mitomycins / pharmacology Neoplasms, Experimental Nitro Compounds / pharmacology Rats Sarcoma, Yoshida / enzymology Tosyl Compounds / pharmacology Vincristine / pharmacology Zinostatin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Chromomycins; 0/Mesylates; 0/Mitomycins; 0/Nitro Compounds; 0/Tosyl Compounds; 11056-06-7/Bleomycin; 147-94-4/Cytarabine; 20830-81-3/Daunorubicin; 24279-91-2/Carbazilquinone; 50-18-0/Cyclophosphamide; 51-21-8/Fluorouracil; 57-22-7/Vincristine; 9014-02-2/Zinostatin; EC 3.1.-/Deoxyribonucleases; EC 3.2.1.31/Glucuronidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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