Document Detail

Beta-cell development: the role of intercellular signals.
MedLine Citation:
PMID:  18834447     Owner:  NLM     Status:  MEDLINE    
Understanding in detail how pancreatic endocrine cells develop is important for many reasons. From a scientific point of view, elucidation of such a complex process is a major challenge. From a more applied point of view, this may help us to better understand and treat specific forms of diabetes. Although a variety of therapeutic approaches are well validated, no cure for diabetes is available. Many arguments indicate that the development of new strategies to cure diabetic patients will require precise understanding of the way beta-cells form during development. This is obvious for a future cell therapy using beta-cells produced from embryonic stem cells. This also holds true for therapeutic approaches based on regenerative medicine. In this review, we summarize our current knowledge concerning pancreatic development and focus on the role of extracellular signals implicated in beta-cell development from pancreatic progenitors.
R Scharfmann; B Duvillie; V Stetsyuk; M Attali; G Filhoulaud; G Guillemain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Diabetes, obesity & metabolism     Volume:  10 Suppl 4     ISSN:  1463-1326     ISO Abbreviation:  Diabetes Obes Metab     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2008-12-09     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  100883645     Medline TA:  Diabetes Obes Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  195-200     Citation Subset:  IM    
INSERM U845, Research Center Growth and Signaling, Université Paris Descartes, Paris, France.
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MeSH Terms
Adult Stem Cells / cytology*,  physiology
Cell Differentiation
Diabetes Mellitus, Type 1 / metabolism*,  physiopathology
Diabetes Mellitus, Type 2 / metabolism*,  physiopathology
Embryonic Stem Cells / cytology*,  physiology
Insulin-Secreting Cells / physiology*
Islets of Langerhans / cytology,  embryology
Precursor Cells, B-Lymphoid / physiology
Regeneration / physiology
Signal Transduction / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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