| Beta-cell development: the role of intercellular signals. | |
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MedLine Citation:
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PMID: 18834447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding in detail how pancreatic endocrine cells develop is important for many reasons. From a scientific point of view, elucidation of such a complex process is a major challenge. From a more applied point of view, this may help us to better understand and treat specific forms of diabetes. Although a variety of therapeutic approaches are well validated, no cure for diabetes is available. Many arguments indicate that the development of new strategies to cure diabetic patients will require precise understanding of the way beta-cells form during development. This is obvious for a future cell therapy using beta-cells produced from embryonic stem cells. This also holds true for therapeutic approaches based on regenerative medicine. In this review, we summarize our current knowledge concerning pancreatic development and focus on the role of extracellular signals implicated in beta-cell development from pancreatic progenitors. |
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Authors:
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R Scharfmann; B Duvillie; V Stetsyuk; M Attali; G Filhoulaud; G Guillemain |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: 10 Suppl 4 ISSN: 1463-1326 ISO Abbreviation: Diabetes Obes Metab Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-06 Completed Date: 2008-12-09 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: England |
Other Details:
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Languages: eng Pagination: 195-200 Citation Subset: IM |
Affiliation:
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INSERM U845, Research Center Growth and Signaling, Université Paris Descartes, Paris, France. scharfmann@necker.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Stem Cells
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cytology*,
physiology Animals Cell Differentiation Diabetes Mellitus, Type 1 / metabolism*, physiopathology Diabetes Mellitus, Type 2 / metabolism*, physiopathology Embryonic Stem Cells / cytology*, physiology Humans Insulin-Secreting Cells / physiology* Islets of Langerhans / cytology, embryology Mice Precursor Cells, B-Lymphoid / physiology Regeneration / physiology Signal Transduction / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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