Document Detail

Beta-catenin and E-cadherin expression in salivary gland tumors.
MedLine Citation:
PMID:  16959701     Owner:  NLM     Status:  MEDLINE    
This study evaluated the expression of E-cadherin and beta-catenin in salivary gland tumors. Twelve biopsy specimens from cases diagnosed as pleomorphic adenoma, 17 adenoid cystic carcinomas, 10 epithelial-myoepithelial carcinomas, and 4 polymorphous low-grade adenocarcinomas were immunohistochemically labeled for E-cadherin and beta-catenin antibodies. Healthy salivary glands were used as controls. Membrane-associated E-cadherin and beta-catenin expression was present in all the tumor types studied. E-cadherin and beta-catenin showed a similar distribution; however, beta-catenin labeling was weaker than that for E-cadherin. In the epithelial-myoepithelial carcinomas, myoepithelial cells exhibited diffuse nuclear staining, although occasional cells presented only focal labeling. Epithelial-myoepithelial carcinomas present changes in [.beta]-catenin expression but the other salivary tumors studied do not, which may reflect divergence in tumorigenesis of this extensive subset of salivary gland tumors.
Cristiane Furuse; Patricia Ramos Cury; Albina Altemani; Décio dos Santos Pinto; Ney Soares de Araújo; Vera Cavalcanti de Araújo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of surgical pathology     Volume:  14     ISSN:  1066-8969     ISO Abbreviation:  Int. J. Surg. Pathol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-09-08     Completed Date:  2006-10-03     Revised Date:  2007-05-24    
Medline Journal Info:
Nlm Unique ID:  9314927     Medline TA:  Int J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  212-7     Citation Subset:  IM    
Department of Oral Pathology, São Leopoldo Mandic Dental Research Institute, Brazil.
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MeSH Terms
Adenocarcinoma / metabolism*,  pathology
Adenoma / metabolism*,  pathology
Cadherins / metabolism*
Carcinoma, Adenoid Cystic / metabolism*,  pathology
Myoepithelioma / metabolism*,  pathology
Retrospective Studies
Salivary Gland Neoplasms / metabolism*,  pathology
Tumor Markers, Biological / metabolism
beta Catenin / metabolism*
Reg. No./Substance:
0/Cadherins; 0/Tumor Markers, Biological; 0/beta Catenin
Comment In:
Int J Surg Pathol. 2007 Apr;15(2):219-20   [PMID:  17478787 ]

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