| Beta-catenin and E-cadherin expression in salivary gland tumors. | |
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MedLine Citation:
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PMID: 16959701 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluated the expression of E-cadherin and beta-catenin in salivary gland tumors. Twelve biopsy specimens from cases diagnosed as pleomorphic adenoma, 17 adenoid cystic carcinomas, 10 epithelial-myoepithelial carcinomas, and 4 polymorphous low-grade adenocarcinomas were immunohistochemically labeled for E-cadherin and beta-catenin antibodies. Healthy salivary glands were used as controls. Membrane-associated E-cadherin and beta-catenin expression was present in all the tumor types studied. E-cadherin and beta-catenin showed a similar distribution; however, beta-catenin labeling was weaker than that for E-cadherin. In the epithelial-myoepithelial carcinomas, myoepithelial cells exhibited diffuse nuclear staining, although occasional cells presented only focal labeling. Epithelial-myoepithelial carcinomas present changes in [.beta]-catenin expression but the other salivary tumors studied do not, which may reflect divergence in tumorigenesis of this extensive subset of salivary gland tumors. |
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Authors:
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Cristiane Furuse; Patricia Ramos Cury; Albina Altemani; Décio dos Santos Pinto; Ney Soares de Araújo; Vera Cavalcanti de Araújo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of surgical pathology Volume: 14 ISSN: 1066-8969 ISO Abbreviation: Int. J. Surg. Pathol. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-09-08 Completed Date: 2006-10-03 Revised Date: 2007-05-24 |
Medline Journal Info:
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Nlm Unique ID: 9314927 Medline TA: Int J Surg Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 212-7 Citation Subset: IM |
Affiliation:
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Department of Oral Pathology, São Leopoldo Mandic Dental Research Institute, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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metabolism*,
pathology Adenoma / metabolism*, pathology Cadherins / metabolism* Carcinoma, Adenoid Cystic / metabolism*, pathology Humans Myoepithelioma / metabolism*, pathology Retrospective Studies Salivary Gland Neoplasms / metabolism*, pathology Tumor Markers, Biological / metabolism beta Catenin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Cadherins; 0/Tumor Markers, Biological; 0/beta Catenin |
| Comments/Corrections | |
Comment In:
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Int J Surg Pathol. 2007 Apr;15(2):219-20
[PMID:
17478787
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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