Document Detail


Beta-catenin and CD44 expression in keratoacanthoma and squamous cell carcinoma of the skin.
MedLine Citation:
PMID:  17679465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD44 and beta-catenin are adhesion molecules expressed on a wide variety of cells. Failure of this expression is believed to lead to disruption of cell-cell adhesion and to neoplasia. The aim of this study was to investigate the staining intensity of CD44 and beta-catenin in keratoacanthomas and squamous cell carcinomas of the skin. The proliferation index, PCNA staining, was also evaluated in these cases. The abnormal expression of beta-catenin significantly predominated in squamous cell carcinomas (n = 20, 76.9%) compared with keratoacanthomas (P = 0.002, chi2 = 7.8). Most keratoacanthomas (n = 11, 61.1%) more frequently showed strong staining intensity with CD44 compared with squamous cell carcinoma (P= 0.001, chi2 = 13.7). The proliferation index was higher in squamous cell carcinoma (P = 0.000, chi2 = 12.8). These findings suggest that CD44 and beta-catenin expression may have an important role in the development of malignancy and in the determination of biological features of keratoacanthoma and squamous cell carcinoma of the skin.
Authors:
Canten Tataroglu; Tuba Karabacak; Duygu Düşmez Apa
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Tumori     Volume:  93     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-08-07     Completed Date:  2007-09-17     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  284-9     Citation Subset:  IM    
Affiliation:
Adnan Menderes University School of Medicine, Department of Pathology, Aydin, Turkey. cantent@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antigens, CD44 / analysis*,  biosynthesis,  genetics
Carcinoma, Squamous Cell / chemistry*,  metabolism,  pathology
Cell Division
Female
Gene Expression Regulation, Neoplastic
Humans
Immunoenzyme Techniques
Keratoacanthoma / metabolism*,  pathology
Male
Middle Aged
Mitotic Index
Neoplasm Invasiveness
Neoplasm Proteins / analysis*,  biosynthesis,  genetics
Proliferating Cell Nuclear Antigen / analysis
Skin
Skin Diseases / metabolism*,  pathology
Skin Neoplasms / chemistry*,  metabolism,  pathology
beta Catenin / analysis*,  biosynthesis,  genetics
Chemical
Reg. No./Substance:
0/Antigens, CD44; 0/CD44 protein, human; 0/CTNNB1 protein, human; 0/Neoplasm Proteins; 0/Proliferating Cell Nuclear Antigen; 0/beta Catenin

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