| Beta-casein nanovehicles for oral delivery of chemotherapeutic drugs. | |
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MedLine Citation:
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PMID: 19616122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bovine beta-casein (beta-CN) is an abundant milk protein that is highly amphiphilic and self-assembles into stable micellar structures in aqueous solutions. Here we introduce a drug-delivery system comprising a model hydrophobic anticancer drug, mitoxantrone (MX), entrapped within beta-CN-based nanoparticles. This novel drug-delivery system allows hydrophobic drugs to be thermodynamically stable in aqueous solutions for oral-delivery applications aimed at treatment of various disorders. The gastric digestibility of beta-CN suggests possible targeting to stomach tumors. Dimethyl sulfoxide (DMSO)-dissolved MX was entrapped in beta-CN nanoparticles by stirring this solution into phosphate-buffered beta-CN solution. High-affinity MX-beta-CN association was found (K(a) = [2.15 +/- 0.30] x 10(6) M(-1)). The optimal nanovehicle formation conditions were 1 mg/mL beta-CN, <or=6% (vol/vol) DMSO in phosphate-buffer solution, 10 mM MX in DMSO, and a MX:beta-CN molar-ratio of approximately 4:1. Under these conditions, particles of 100 to 300-nm diameter were formed. beta-CN nanoparticles may serve as effective oral-delivery nanovehicles for solubilization and stabilization of hydrophobic drugs. FROM THE CLINICAL EDITOR: Bovine beta-casein (beta-CN) is an abundant milk-protein that is highly amphiphilic and self-assembles into stable micellar-structures in aqueous solutions. beta-CN nanoparticles may serve as effective oral-delivery nanovehicles for solubilization and stabilization of hydrophobic drugs, as demonstrated in this study utilizing methotrexate. |
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Authors:
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Alina Shapira; Yehuda G Assaraf; Yoav D Livney |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-16 |
Journal Detail:
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Title: Nanomedicine : nanotechnology, biology, and medicine Volume: 6 ISSN: 1549-9642 ISO Abbreviation: Nanomedicine Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-09 Completed Date: 2010-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233142 Medline TA: Nanomedicine Country: United States |
Other Details:
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Languages: eng Pagination: 119-26 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Russell Berrie Nanotechnology Institute, Technion, Israel Institute of Technology, Haifa, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Caseins / metabolism* Cattle Drug Carriers / chemistry* Fluorescence Micelles Mitoxantrone / administration & dosage*, pharmacology* Nanoparticles / chemistry* Particle Size Temperature Time Factors Tryptophan / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Caseins; 0/Drug Carriers; 0/Micelles; 65271-80-9/Mitoxantrone; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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