Document Detail

Beta-carotene supplementation attenuates cardiac remodeling induced by one-month tobacco-smoke exposure in rats.
MedLine Citation:
PMID:  16387745     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objectives were to analyze the cardiac effects of exposure to tobacco smoke (ETS), for a period of 30 days, alone and in combination with beta-carotene supplementation (BC).
RESEARCH METHODS AND PROCEDURES: Rats were allocated into: Air (control, n = 13); Air + BC (n = 11); ETS (n = 11); and BC + ETS (n = 9). In Air + BC and BC + ETS, 500 mg of BC were added to the diet. After three months of randomization, cardiac structure and function were assessed by echocardiogram. After that, animals were euthanized and morphological data were analyzed post-mortem. One-way and two-way ANOVA were used to assess the effects of ETS, BC and the interaction between ETS and BC on the variables.
RESULTS: ETS presented smaller cardiac output (0.087 +/- 0.001 vs. 0.105 +/- 0.004 l/min; p = 0.007), higher left ventricular diastolic diameter (19.6 +/- 0.5 vs. 18.0 +/- 0.5 mm/kg; p = 0.024), higher left ventricular (2.02 +/- 0.05 vs. 1.70 +/- 0.03 g/kg; p < 0.001) and atrium (0.24 +/- 0.01 vs. 0.19 +/- 0.01 g/kg; p = 0.003) weight, adjusted to body weight of animals, and higher values of hepatic lipid hydroperoxide (5.32 +/- 0.1 vs. 4.84 +/- 0.1 nmol/g tissue; p = 0.031) than Air. However, considering those variables, there were no differences between Air and BC + ETS (0.099 +/- 0.004 l/min; 19.0 +/- 0.5 mm/kg; 1.83 +/- 0.04 g/kg; 0.19 +/- 0.01 g/kg; 4.88 +/- 0.1 nmol/g tissue, respectively; p > 0.05). Ultrastructural alterations were found in ETS: disorganization or loss of myofilaments, plasmatic membrane infolding, sarcoplasm reticulum dilatation, polymorphic mitochondria with swelling and decreased cristae. In BC + ETS, most fibers showed normal morphological aspects.
CONCLUSION: One-month tobacco-smoke exposure induces functional and morphological cardiac alterations and BC supplementation attenuates this ventricular remodeling process.
Leonardo A M Zornoff; Luiz S Matsubara; Beatriz B Matsubara; Marina P Okoshi; Katashi Okoshi; Maeli Dal Pai-Silva; Robson F Carvalho; Antonio C Cicogna; Carlos R Padovani; Ethel L Novelli; Rosangela Novo; Alvaro O Campana; Sergio A R Paiva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-30
Journal Detail:
Title:  Toxicological sciences : an official journal of the Society of Toxicology     Volume:  90     ISSN:  1096-6080     ISO Abbreviation:  Toxicol. Sci.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-10     Completed Date:  2006-03-30     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  9805461     Medline TA:  Toxicol Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
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MeSH Terms
Antioxidants / administration & dosage*
Cardiomegaly / chemically induced,  metabolism,  pathology
Heart Ventricles / drug effects*,  pathology,  physiopathology
Inhalation Exposure
Lipid Peroxides / blood
Myocardium / ultrastructure
Organ Size / drug effects
Rats, Wistar
Ventricular Remodeling / drug effects*
beta Carotene / administration & dosage*
Reg. No./Substance:
0/Antioxidants; 0/Lipid Peroxides; 0/Smoke; 01YAE03M7J/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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