Document Detail

Beta-carotene and the application of transcriptomics in risk-benefit evaluation of natural dietary components.
MedLine Citation:
PMID:  15949680     Owner:  NLM     Status:  MEDLINE    
Beta-carotene is a natural food component that is present in fruits and vegetables and is also used as a food colorant and a supplement. Beta-carotene is an anti-oxidant and a source of vitamin A. It is endowed with health beneficial properties, but a number of studies showed that with high intakes it may increase the risk for lung cancer in at risk individuals (heavy smokers, asbestos workers and alcohol users). To establish the window of benefit, it is necessary to identify early markers of effect and to obtain insight in the mechanism of action of beta-carotene, in the absence and presence of environmental risk factors. Genomics technologies are well suited to dissect the mechanisms of action and identify the markers of effect. Human cell lines can be used to analyse the effects of beta-carotene, but exposure studies with beta-carotene show that cell lines display a widely variant behaviour, which hampers translation to the in vivo situation in humans. Alternatively, animal studies can be used. Especially the ferret seems to be a good model, but little sequence information of this species is available. However, heterologous hybridization on human cDNA seems possible and provides and a new tool for molecular analysis of health effects of beta-carotene.
Jaap Keijer; Annelies Bunschoten; Andreu Palou; Nicole L W Franssen-van Hal
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-01-26
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1740     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-13     Completed Date:  2005-08-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  139-46     Citation Subset:  IM    
RIKILT-Institute of Food Safety, Food Bioactives Group. Bornsesteeg 45, P.O. Box 230, 6700 AE, Wageningen, The Netherlands.
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MeSH Terms
Antioxidants / pharmacology*,  therapeutic use,  toxicity
Cell Line
Clinical Trials as Topic
Dietary Supplements / toxicity
Dietetics* / standards
Lung Neoplasms / prevention & control
Models, Animal
No-Observed-Adverse-Effect Level
Oligonucleotide Array Sequence Analysis
Risk Assessment
beta Carotene / administration & dosage,  pharmacology*,  therapeutic use,  toxicity
Reg. No./Substance:
0/Antioxidants; 7235-40-7/beta Carotene

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