Document Detail

Beta-blockers and weight change in patients with chronic heart failure.
MedLine Citation:
PMID:  22385944     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: There is an inverse association between body mass and mortality in patients with chronic heart failure (CHF). Beta-blockers have been associated with weight gain. We wanted to examine the relation between beta-blocker use and weight in a population of patients with CHF.
METHODS AND RESULTS: We weighed 276 patients presenting with CHF (mean age 71.3 ± 9.5 years, 72.8% male). None were taking a beta-blocker at presentation, but all had started by 4 months' follow-up. The patients were reweighed after 1 year. There was an increase in weight (0.9 ± 7.0 kg; P = .03) and body mass index (0.2 ± 2.4 kg/m(2); P = .02). Patients in New York Heart Association (NYHA) functional class III or IV had no significant weight change, whereas those in class I or II had an increase of 1.62 kg (P < .0001). In patients who had no peripheral edema at baseline or 1 year, there was a greater increase in weight (1.3 ± 6.9 kg; P = .01).
CONCLUSIONS: Beta-blocker use and intensification of heart failure treatment is associated with weight gain in CHF. The increase is greater in those who are nonedematous and tends to occur in patients with NYHA functional class I and II symptoms.
Ben W J Boxall; Andrew L Clark
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Publication Detail:
Type:  Journal Article     Date:  2011-12-03
Journal Detail:
Title:  Journal of cardiac failure     Volume:  18     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Cardiology, Hull York Medical School, University of Hull, Kingston-upon-Hull, United Kingdom.
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