Document Detail


Beta blockers therapy is associated with improved left ventricular systolic function and sustained exercise capacity in elderly patients with heart failure. CIBIS-ELD sub-study.
MedLine Citation:
PMID:  23147689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Exercise capacity is critical for therapy and prognosis in patients with heart failure (HF). Effect of beta-blockers (BB) on exercise capacity in elderly patients with HF remains unclear.
OBJECTIVES: To assess contribution of BB to functional capacity and left ventricular (LV) function in the elderly with HF.
DESIGN: According to the protocol of CIBIS-ELD study group, elderly patients were treated with BB during 12 weeks. In CPET subgroup, an integral part of the CIBIS ELD study group, patients were performed Doppler echocardiography and cardiopulmonary exercise testing (CPET) before BB therapy and after 12 weeks.
SETTING: Randomized patients with HF beta blockers naïve.
PARTICIPANTS: thirty patients with HF aged over 65 years were included in CPET subgroup, while 847 were incorporated in CIBIS ELD study group.
RESULTS: Heart rate (HR) and systolic blood pressure (SBP) after BB significantly decreased at rest (p<0.001) and during exercise (p<0.05), with sustained level of peak VO2. Observed changes of resting HR and peak HR were closely correlated (p<0.001). Significant improvement of LV ejection fraction after BB was obtained (p=0.003) and symptoms of breathlessness were reduced (p=0.001). Left ventricular diastolic dysfunction at rest significantly contributed to exercise capacity (p=0.019).
CONCLUSIONS: Beta-blockers in elderly patients with HF are related to a significant decrease of HR and SBP, improvement of systolic LV function and sustained exercise tolerance. Resting LV diastolic dysfunction is strongly associated with lower exercise capacity.
Authors:
Milica Dekleva; Hans-Dirk Düngen; Götz Gelbrich; Simone Incrot; Jelena Suzic Lazic; Milena Pavlovic Kleut; Elvis Tahirovic; Finn Waagstein
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-11-12
Journal Detail:
Title:  Aging clinical and experimental research     Volume:  24     ISSN:  1720-8319     ISO Abbreviation:  Aging Clin Exp Res     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-03-26     Completed Date:  2013-09-16     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101132995     Medline TA:  Aging Clin Exp Res     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  675-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / administration & dosage,  therapeutic use*
Aged
Aging / physiology
Bisoprolol / administration & dosage
Blood Pressure / drug effects
Carbazoles / administration & dosage
Exercise Test
Female
Heart Failure / drug therapy*,  physiopathology*
Heart Rate / drug effects
Humans
Male
Propanolamines / administration & dosage
Prospective Studies
Ventricular Function, Left / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol; Y41JS2NL6U/Bisoprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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