Document Detail

Beta-blockers prevent cardiac events in Japanese patients with myocardial infarction.
MedLine Citation:
PMID:  14695467     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although the favorable effects of beta-blockers in the treatment of myocardial infarction (MI) have been repeatedly demonstrated in Western countries, administration of this drug has been limited in Japan. METHODS AND RESULTS: The study group of 1,896 patients with MI was retrospectively divided into 1,029 patients treated by beta-blockers and 867 not treated by beta-blockers, and the incidences of cardiac events, consisting of recurrent MI, death because of worsening heart failure, and sudden death, and cardiovascular events, comprising cardiac events and stroke, were compared in both groups. There were 45 cardiac events (4.4%, 30.1 patients/1,000 patients. year) among the beta-blocker group, which was significantly less than the 56 cardiac events (6.5%, 52.3 patients/1,000 patients. year) among the no-beta-blocker group (p<0.05). The total mortality was 92 (8.9%, 61.6 patients/1,000 patients. year) and 124 (14.3%, 115.8 patients/1,000 patients. year), respectively, and cardiac death occurred in 42 (4.1%, 28.1 patients/1,000 patients. year) and 53 (6.1%, 49.5 patients/1,000 patients. year), respectively, indicating that both these events occurred significantly less in the beta-blocker group (p<0.01 and p<0.05). CONCLUSIONS: Beta-blockers prevent cardiac events in Japanese patients with MI. However, a placebo-controlled, double-blind, multicenter, clinical trial conducted on a large scale in Japan would further contribute more precise information of the useful effects of beta-blockers.
Kinji Ishikawa; Masaru Miyataka; Akio Kimura; Norihiro Takeda; Yutaka Hirano; Takahiro Hayashi; Ken Kanamasa;
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  68     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-25     Completed Date:  2004-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  59-67     Citation Subset:  IM    
Department of Cardiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Blood Urea Nitrogen
Death, Sudden, Cardiac
Heart Diseases / drug therapy,  mortality,  prevention & control*
Heart Rate
Middle Aged
Myocardial Infarction / classification,  drug therapy*,  mortality
Retrospective Studies
Survival Analysis
Reg. No./Substance:
0/Adrenergic beta-Antagonists

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