Document Detail

Beta-blockers, exercise, and the immune system in men with coronary artery disease.
MedLine Citation:
PMID:  11932564     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of the present study was to examine the effect of aerobic exercise training on the immune system in coronary artery disease patients treated with beta-blockers. METHODS: Twenty-five patients (46.1 +/- 2 yr) treated with atenolol, a beta-blocker agent, for 3 months before exercising were divided randomly into two groups: 15 underwent an aerobic exercise training program for 12 wk at 65-70% of their work capacity, whereas the other 10 patients served as controls. RESULTS: After training, levels of CD4 and CD8 cells were significantly (P < 0.05) higher and concomitantly the CD4/CD8 ratio decreased significantly (P < 0.05) in the exercising group compared with the control group. CONCLUSIONS: Data suggest that coronary artery disease patients exercising aerobically at 65-70% of their work capacity gain a statistically significant higher lymphocyte T cell function as compared with their untrained counterparts.
Michael Sagiv; David Ben-Sira; Ehud Goldhammer
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  34     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-04     Completed Date:  2002-04-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  587-91     Citation Subset:  IM; S    
The Sports Medicine and Rehabilitation Division, The Zinman College of Physical Education, Wingate Institute, Netanya 42902, Israel.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Atenolol / therapeutic use*
CD4-CD8 Ratio
Coronary Artery Disease / drug therapy,  immunology*,  physiopathology
Exercise / physiology*
Middle Aged
T-Lymphocytes / immunology
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 29122-68-7/Atenolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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