| Beta blocker effects on heart rate during sleep: a placebo-controlled polysomnographic study with normotensive males. | |
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MedLine Citation:
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PMID: 1687425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the effect of beta blockers on heart rate (HR) at rest, during exercise, and by ambulatory electrocardiography during the day and night has been studied extensively, data on the effect of these drugs on heart rate during the various stages of sleep are not available. We performed overnight polysomnography and exercise testing in a randomized, double-blind, placebo-controlled, Latin square crossover study of four beta blockers with different ancillary properties (atenolol 100 mg daily, metoprolol 100 mg, pindolol 10 mg, and propranolol 80 mg), on 30 healthy men aged 23-40 years (29.4 +/- 4.3) (mean +/- SD). At rest pindolol increased HR by 4.7 beats/min +/- 13.1 (p less than 0.05), while beta blockers without intrinsic sympathomimetic activity (ISA) decreased HR (p less than 0.0001) by 6.1 +/- 8.8 (atenolol), 5.8 +/- 8.4 (propranolol), and 5.0 +/- 9.4 (metoprolol). Exercise at 125 W increased HR on placebo by 76.4 +/- 18.4 beats. Compared to placebo all beta blockers were associated with lower (p less than 0.0001) exercise HR by 18.3 +/- 23.2 atenolol, 21.1 +/- 15.5 metoprolol, 16.8 +/- 14.1 pindolol, and 20.8 +/- 13.1 propranolol [not significant (NS) among beta blockers]. Thus the effect of beta blockers on heart rate was magnified during exercise. Mean and maximum HR were higher in rapid eye movement (REM) than in nonREM (NREM) sleep (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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R C Rosen; J B Kostis; L G Seltzer; L S Taska; B C Holzer |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Sleep Volume: 14 ISSN: 0161-8105 ISO Abbreviation: Sleep Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1992-06-04 Completed Date: 1992-06-04 Revised Date: 2009-01-29 |
Medline Journal Info:
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Nlm Unique ID: 7809084 Medline TA: Sleep Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 43-7 Citation Subset: IM |
Affiliation:
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U.M.D.N.J.-Robert Wood Johnson Medical School, Department of Psychiatry, Piscataway 08854. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Atenolol / pharmacology Cerebral Cortex / drug effects Double-Blind Method Electrocardiography / drug effects Electroencephalography / drug effects* Exercise Test / drug effects Heart Rate / drug effects* Humans Male Metoprolol / pharmacology Monitoring, Physiologic Pindolol / pharmacology Propranolol / pharmacology Sleep Stages / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL33960/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 13523-86-9/Pindolol; 29122-68-7/Atenolol; 37350-58-6/Metoprolol; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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