Document Detail

Beta blocker effects on heart rate during sleep: a placebo-controlled polysomnographic study with normotensive males.
MedLine Citation:
PMID:  1687425     Owner:  NLM     Status:  MEDLINE    
Although the effect of beta blockers on heart rate (HR) at rest, during exercise, and by ambulatory electrocardiography during the day and night has been studied extensively, data on the effect of these drugs on heart rate during the various stages of sleep are not available. We performed overnight polysomnography and exercise testing in a randomized, double-blind, placebo-controlled, Latin square crossover study of four beta blockers with different ancillary properties (atenolol 100 mg daily, metoprolol 100 mg, pindolol 10 mg, and propranolol 80 mg), on 30 healthy men aged 23-40 years (29.4 +/- 4.3) (mean +/- SD). At rest pindolol increased HR by 4.7 beats/min +/- 13.1 (p less than 0.05), while beta blockers without intrinsic sympathomimetic activity (ISA) decreased HR (p less than 0.0001) by 6.1 +/- 8.8 (atenolol), 5.8 +/- 8.4 (propranolol), and 5.0 +/- 9.4 (metoprolol). Exercise at 125 W increased HR on placebo by 76.4 +/- 18.4 beats. Compared to placebo all beta blockers were associated with lower (p less than 0.0001) exercise HR by 18.3 +/- 23.2 atenolol, 21.1 +/- 15.5 metoprolol, 16.8 +/- 14.1 pindolol, and 20.8 +/- 13.1 propranolol [not significant (NS) among beta blockers]. Thus the effect of beta blockers on heart rate was magnified during exercise. Mean and maximum HR were higher in rapid eye movement (REM) than in nonREM (NREM) sleep (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
R C Rosen; J B Kostis; L G Seltzer; L S Taska; B C Holzer
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Sleep     Volume:  14     ISSN:  0161-8105     ISO Abbreviation:  Sleep     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1992-06-04     Completed Date:  1992-06-04     Revised Date:  2009-01-29    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  IM    
U.M.D.N.J.-Robert Wood Johnson Medical School, Department of Psychiatry, Piscataway 08854.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Atenolol / pharmacology
Cerebral Cortex / drug effects
Double-Blind Method
Electrocardiography / drug effects
Electroencephalography / drug effects*
Exercise Test / drug effects
Heart Rate / drug effects*
Metoprolol / pharmacology
Monitoring, Physiologic
Pindolol / pharmacology
Propranolol / pharmacology
Sleep Stages / drug effects*
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 13523-86-9/Pindolol; 29122-68-7/Atenolol; 37350-58-6/Metoprolol; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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