Document Detail

Beta-blockade intolerance in anthracycline-induced cardiomyopathy.
MedLine Citation:
PMID:  15992949     Owner:  NLM     Status:  MEDLINE    
Beta-blockade efficiency and safety in anthracycline induced cardiomyopathy (AIC) are poorly documented. Cardiac Heart Failure (CHF) due to an AIC has haemodynamic and histologic particularities: only mild ventricular dilatation, restriction pattern and myocardial and endocardial fibrous thickening. Therefore, beta blockade therapy initiation may cause heart failure decompensation by absence of the usual left ventricular adaptation (improvement of left ventricular compliance allowing maintenance of stroke volume). We describe an AIC patient in whom a first beta-blockade initial administration caused a global cardiac failure; after stabilisation, one month later, a second attempt caused a new cardiac failure. We raise the question of beta-blockade safety in restrictive cardiomyopathies.
Jean-Yves Tabet; Philippe Meurin; Ahmed Ben Driss; Xavier Berthaux; Hélène Weber; Nathalie Renaud; Alain Cohen Solal
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Publication Detail:
Type:  Case Reports; Letter     Date:  2005-07-01
Journal Detail:
Title:  International journal of cardiology     Volume:  106     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-02     Completed Date:  2006-03-16     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  132-4     Citation Subset:  IM    
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MeSH Terms
Adrenergic beta-Antagonists / adverse effects*,  therapeutic use
Anthracyclines / adverse effects*
Breast Neoplasms / drug therapy*
Cardiomyopathy, Dilated / chemically induced*,  drug therapy*,  ultrasonography
Middle Aged
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Anthracyclines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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