Document Detail


Beta-amyloid burden is not associated with rates of brain atrophy.
MedLine Citation:
PMID:  17894374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To test the hypothesis that beta-amyloid (Abeta) burden is associated with rates of brain atrophy.
METHODS: Forty-five subjects who had been prospectively studied, died, and had an autopsy diagnosis of low, intermediate, or high probability of Alzheimer's disease who had two volumetric head magnetic resonance imaging scans were identified. Compact and total (compact + diffuse) Abeta burden was measured using a computerized image analyzer with software program to detect the proportion of gray matter occupied by Abeta. Visual ratings of Abeta burden were also performed. The boundary shift integral was used to calculate change over time in whole-brain and ventricular volume. All boundary shift integral results were annualized by adjusting for scan interval. Demographics, cognitive measures, clinical diagnoses, apolipoprotein E genotype, neurofibrillary tangle (NFT) pathology, and vascular lesion burden were determined.
RESULTS: There was no correlation between compact or total Abeta burden, or visual Abeta ratings, and rates of brain loss or ventricular expansion in all subjects. However, significant correlations were observed between rates of brain loss and age, Braak NFT stage, and change over time in cognitive measures. These features also correlated with rates of ventricular expansion. The rates of brain loss and ventricular expansion were greater in demented compared with nondemented subjects.
INTERPRETATION: These findings suggest that rate of brain volume loss is not determined by the amount of insoluble Abeta in the gray matter.
Authors:
Keith A Josephs; Jennifer L Whitwell; Zeshan Ahmed; Maria M Shiung; Stephen D Weigand; David S Knopman; Bradley F Boeve; Joseph E Parisi; Ronald C Petersen; Dennis W Dickson; Clifford R Jack
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of neurology     Volume:  63     ISSN:  1531-8249     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-04     Completed Date:  2008-04-03     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  204-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age of Onset
Aged
Aged, 80 and over
Alzheimer Disease / metabolism,  pathology*,  physiopathology*
Amyloid beta-Peptides / analysis,  metabolism*
Apolipoproteins E / genetics
Atrophy / etiology,  pathology*,  physiopathology
Autopsy
Brain / metabolism,  pathology*,  physiopathology
Disease Progression
Female
Genotype
Humans
Lateral Ventricles / pathology
Magnetic Resonance Imaging
Male
Middle Aged
Plaque, Amyloid / metabolism,  pathology*
Predictive Value of Tests
Prospective Studies
Severity of Illness Index
Time Factors
Grant Support
ID/Acronym/Agency:
K12 HD049078/HD/NICHD NIH HHS; K12 HD049078-01/HD/NICHD NIH HHS; K12 HD49078/HD/NICHD NIH HHS; P50 AG016574/AG/NIA NIH HHS; P50 AG016574-090004/AG/NIA NIH HHS; P50 AG16574/AG/NIA NIH HHS; R01 AG011378/AG/NIA NIH HHS; R01 AG011378-15/AG/NIA NIH HHS; R01 AG11378/AG/NIA NIH HHS; U01 AG006786/AG/NIA NIH HHS; U01 AG006786-23/AG/NIA NIH HHS; U01 AG06786/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Amyloid beta-Peptides; 0/Apolipoproteins E
Comments/Corrections

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