| Beta-amyloid burden is not associated with rates of brain atrophy. | |
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MedLine Citation:
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PMID: 17894374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test the hypothesis that beta-amyloid (Abeta) burden is associated with rates of brain atrophy. METHODS: Forty-five subjects who had been prospectively studied, died, and had an autopsy diagnosis of low, intermediate, or high probability of Alzheimer's disease who had two volumetric head magnetic resonance imaging scans were identified. Compact and total (compact + diffuse) Abeta burden was measured using a computerized image analyzer with software program to detect the proportion of gray matter occupied by Abeta. Visual ratings of Abeta burden were also performed. The boundary shift integral was used to calculate change over time in whole-brain and ventricular volume. All boundary shift integral results were annualized by adjusting for scan interval. Demographics, cognitive measures, clinical diagnoses, apolipoprotein E genotype, neurofibrillary tangle (NFT) pathology, and vascular lesion burden were determined. RESULTS: There was no correlation between compact or total Abeta burden, or visual Abeta ratings, and rates of brain loss or ventricular expansion in all subjects. However, significant correlations were observed between rates of brain loss and age, Braak NFT stage, and change over time in cognitive measures. These features also correlated with rates of ventricular expansion. The rates of brain loss and ventricular expansion were greater in demented compared with nondemented subjects. INTERPRETATION: These findings suggest that rate of brain volume loss is not determined by the amount of insoluble Abeta in the gray matter. |
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Authors:
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Keith A Josephs; Jennifer L Whitwell; Zeshan Ahmed; Maria M Shiung; Stephen D Weigand; David S Knopman; Bradley F Boeve; Joseph E Parisi; Ronald C Petersen; Dennis W Dickson; Clifford R Jack |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of neurology Volume: 63 ISSN: 1531-8249 ISO Abbreviation: Ann. Neurol. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-03-04 Completed Date: 2008-04-03 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 204-12 Citation Subset: IM |
Affiliation:
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Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA. josephs.keith@mayo.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Aged Aged, 80 and over Alzheimer Disease / metabolism, pathology*, physiopathology* Amyloid beta-Peptides / analysis, metabolism* Apolipoproteins E / genetics Atrophy / etiology, pathology*, physiopathology Autopsy Brain / metabolism, pathology*, physiopathology Disease Progression Female Genotype Humans Lateral Ventricles / pathology Magnetic Resonance Imaging Male Middle Aged Plaque, Amyloid / metabolism, pathology* Predictive Value of Tests Prospective Studies Severity of Illness Index Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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K12 HD049078-01/HD/NICHD NIH HHS; K12 HD49078/HD/NICHD NIH HHS; P50 AG016574/AG/NIA NIH HHS; P50 AG016574-090004/AG/NIA NIH HHS; P50 AG16574/AG/NIA NIH HHS; R01 AG011378/AG/NIA NIH HHS; R01 AG011378-15/AG/NIA NIH HHS; R01 AG11378/AG/NIA NIH HHS; U01 AG006786-23/AG/NIA NIH HHS; U01 AG06786/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Peptides; 0/Apolipoproteins E |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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