Document Detail


Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia.
MedLine Citation:
PMID:  16899997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Measurement of tau-protein and beta-amyloid(1-42 )(Abeta42) in cerebrospinal fluid (CSF) has gained increasing acceptance in the differential diagnosis of Alzheimer's disease. We investigated CSF tau-protein and Abeta42 concentrations in 73 patients with advanced idiopathic Parkinson's disease with dementia (PDD) and 23 patients with idiopathic Parkinson's disease without dementia (PD) and in a comparison group of 41 non-demented neurological patients (CG) using commercially available enzyme-linked-immunoabsorbant-assay (ELISA). tau-Protein levels were statistically significantly higher and Abeta42 lower in the PDD patients compared to PD patients and the CG. This observation was most marked (p < 0.05) in a subgroup of patients with PDD carrying the apolipoprotein genotype epsilon3/epsilon3. The distribution of the apolipoprotein genotypes in PDD and PD patients was similar to that of the CG. Although a significant difference in tau-protein values was observed between PDD and CG, no diagnostic cut-off value was established. These findings suggest that such protein CSF changes may help to support the clinical diagnosis of cognitive decline in PD and that there may be apolipoprotein-E-isoform-specific differences in CSF protein regulation in advanced PDD.
Authors:
Brit Mollenhauer; Claudia Trenkwalder; Nicolas von Ahsen; Mirko Bibl; Petra Steinacker; Peter Brechlin; Jan Schindehuette; Sigrid Poser; Jens Wiltfang; Markus Otto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-07
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  22     ISSN:  1420-8008     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2006  
Date Detail:
Created Date:  2006-08-31     Completed Date:  2006-10-30     Revised Date:  2008-03-24    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  200-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2006 S. Karger AG, Basel
Affiliation:
Department of Neurology,Georg-August University, Kassel, Germany. bmollenhauer@ics.bwh.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alleles
Amyloid beta-Protein / cerebrospinal fluid*
Apolipoproteins E / genetics
Dementia / cerebrospinal fluid*,  etiology*,  psychology
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged
Neuropsychological Tests
Parkinson Disease / cerebrospinal fluid*,  complications*,  psychology
Peptide Fragments / cerebrospinal fluid*
Psychiatric Status Rating Scales
alpha-Synuclein / cerebrospinal fluid
tau Proteins / cerebrospinal fluid*
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Apolipoproteins E; 0/Peptide Fragments; 0/alpha-Synuclein; 0/amyloid beta-protein (1-42); 0/tau Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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