| Beta-aminocinnamonitriles as potential antiinflammatory agents. | |
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MedLine Citation:
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PMID: 1121013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A number of beta-aminocinnamonitriles have been prepared by the reaction of salts of acetonitrile and propionitrile with benzonitrile. These materials were evaluated in the carrageenan antiinflammatory screen in Royal Hart, Wistar strain rats. Despite good weight gains in the parent molecule, beta-aminocinnamonitrile (1), only marginal activity was found in related compounds and some possible "metabolites." |
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Authors:
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S A Lang; E Cohen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 18 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 1975 Apr |
Date Detail:
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Created Date: 1975-06-21 Completed Date: 1975-06-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 441-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / chemical synthesis*, therapeutic use Carrageenan Cinnamates / chemical synthesis*, therapeutic use Edema / chemically induced, drug therapy Erythema / drug therapy, etiology Guinea Pigs Nitriles / chemical synthesis*, therapeutic use Rats Ultraviolet Rays |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Cinnamates; 0/Nitriles; 9000-07-1/Carrageenan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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