Document Detail


Beta-adrenoceptor inhibition for induction of acute cardiac failure in pigs.
MedLine Citation:
PMID:  10778785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For the testing of heart assist devices most animal models of acute cardiac failure that are usually used show certain disadvantages. We therefore developed a new method using the beta-adrenoceptor antagonist carazolol. We administered a bolus injection of 1 mg/kg followed by a continuous infusion of 1 mg/kg/h in adult German 'Landrasse' pigs. Blood pressure, heart rate, cardiac output and maximum left ventricular pressure rise time showed a significant (P < 0.05) reduction of the control value varying between 40% and 59%. The method is suitable for the testing of surgical approaches in heart failure.
Authors:
T Petzold; P Feindt; M D Menger; E Gams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animals     Volume:  33     ISSN:  0023-6772     ISO Abbreviation:  Lab. Anim.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-05-09     Completed Date:  2000-05-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0112725     Medline TA:  Lab Anim     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  366-71     Citation Subset:  IM    
Affiliation:
Department of Thoracic and Cardiovascular Surgery, Heinrich-Heine-Universität Düsseldorf, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adrenergic beta-Antagonists / toxicity*
Animals
Disease Models, Animal
Female
Heart Failure / chemically induced*,  physiopathology
Hemodynamics / drug effects
Propanolamines / toxicity*
Swine
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 57775-29-8/carazolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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