| Beta-adrenoceptor inhibition for induction of acute cardiac failure in pigs. | |
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MedLine Citation:
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PMID: 10778785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For the testing of heart assist devices most animal models of acute cardiac failure that are usually used show certain disadvantages. We therefore developed a new method using the beta-adrenoceptor antagonist carazolol. We administered a bolus injection of 1 mg/kg followed by a continuous infusion of 1 mg/kg/h in adult German 'Landrasse' pigs. Blood pressure, heart rate, cardiac output and maximum left ventricular pressure rise time showed a significant (P < 0.05) reduction of the control value varying between 40% and 59%. The method is suitable for the testing of surgical approaches in heart failure. |
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Authors:
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T Petzold; P Feindt; M D Menger; E Gams |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Laboratory animals Volume: 33 ISSN: 0023-6772 ISO Abbreviation: Lab. Anim. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 2000-05-09 Completed Date: 2000-05-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0112725 Medline TA: Lab Anim Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 366-71 Citation Subset: IM |
Affiliation:
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Department of Thoracic and Cardiovascular Surgery, Heinrich-Heine-Universität Düsseldorf, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adrenergic beta-Antagonists / toxicity* Animals Disease Models, Animal Female Heart Failure / chemically induced*, physiopathology Hemodynamics / drug effects Propanolamines / toxicity* Swine |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Propanolamines; 57775-29-8/carazolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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