Document Detail


Beta-adrenoceptor changes in mononuclear leukocytes during pregnancy.
MedLine Citation:
PMID:  7770466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leukocyte beta 2-adrenoceptors mirror similar receptors in the uterus. This study examined changes in beta 2-adrenoceptors and in cAMP production during pregnancy using peripheral mononuclear leukocytes isolated from 17 pregnant women and 5 nonpregnant controls. beta 2-Adrenoceptor density was determined by 125I-pindolol binding. cAMP production under basal and stimulated (10 microM isoproterenol) conditions was determined by radioimmunoassay. Groups were compared by unpaired t test. There was a nonsignificant decrease in the density of beta-adrenoceptors during pregnancy. While basal cAMP production was unchanged during pregnancy, stimulated cAMP production was decreased (44% of control, P < 0.001; 95% CI 33%-56%). Stimulated cAMP production per receptor was lower in leukocytes from pregnant women and was not a constant relationship, but was increased markedly in leukocytes having fewer than 400 beta-adrenoceptor sites per cell. There are significant changes in the coupling of beta-adrenoceptors to cAMP production during pregnancy without changes in beta-receptor density, affinity, or basal cAMP production.
Authors:
U C Nwosu; P J Rice
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  209     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-06     Completed Date:  1995-07-06     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-62     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cyclic AMP / metabolism
Female
Humans
Leukocytes, Mononuclear / metabolism*
Pindolol / metabolism
Pregnancy
Radioligand Assay
Receptors, Adrenergic, beta / metabolism*
Signal Transduction
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 13523-86-9/Pindolol; 60-92-4/Cyclic AMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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