| Beta-adrenoceptor blocker pharmacokinetics and the oral contraceptive pill. | |
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MedLine Citation:
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PMID: 6146344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Higher AUC and Cmax values were obtained for metoprolol, oxprenolol and propranolol in groups receiving the low-dose oestrogen-ethinyl oestradiol oral contraceptive, but statistical significance was reached only with metoprolol AUC. The oral contraceptive had the opposite effect on acebutolol AUC and Cmax but this was not significant. The oral contraceptive had no detectable effects on the tmax and t 1/2 values of any of the beta-adrenoceptor blockers. |
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Authors:
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M J Kendall; D B Jack; C P Quarterman; S R Smith; R Zaman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 17 Suppl 1 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1984 |
Date Detail:
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Created Date: 1984-09-13 Completed Date: 1984-09-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 87S-89S Citation Subset: IM; J |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acebutolol
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metabolism Adrenergic beta-Antagonists / metabolism* Contraceptives, Oral / pharmacology* Contraceptives, Oral, Hormonal / pharmacology* Drug Interactions Female Humans Kinetics Metoprolol / metabolism Oxprenolol / metabolism Propranolol / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Contraceptives, Oral; 0/Contraceptives, Oral, Hormonal; 37350-58-6/Metoprolol; 37517-30-9/Acebutolol; 525-66-6/Propranolol; 6452-71-7/Oxprenolol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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