Document Detail

Beta-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinase.
MedLine Citation:
PMID:  8789956     Owner:  NLM     Status:  MEDLINE    
To identify the protein kinases regulating synaptic NMDA receptors, as well as the conditions favoring enhancement of NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) by phosphorylation, we studied the effects of kinase activation and inhibition in hippocampal neurons. Inhibition of cAMP-dependent protein kinase (PKA) prevented recovery of NMDA receptors from calcineurin-mediated dephosphorylation induced by synaptic activity, suggesting that tonically active PKA phosphorylates receptors during quiescent periods. Conversely, elevation of PKA activity by forskolin, cAMP analogs, or the beta-adrenergic receptor agonists norepinephrine and isoproterenol overcame the ability of calcineurin to depress the amplitude of NMDA EPSCs. Thus, stimulation of beta-adrenergic receptors during excitatory synaptic transmission can increase charge transfer and Ca2+ influx through NMDA receptors.
I M Raman; G Tong; C E Jahr
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  16     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1997-01-06     Completed Date:  1997-01-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  415-21     Citation Subset:  IM    
Vollum Institute Oregon Health Sciences University, Portland 97201, USA.
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MeSH Terms
Adrenergic beta-Agonists / pharmacology
Calmodulin-Binding Proteins / pharmacology
Cyclic AMP / analogs & derivatives
Cyclic AMP-Dependent Protein Kinases / physiology*
Forskolin / pharmacology
Hippocampus / cytology,  metabolism,  physiology
Neurons / metabolism,  physiology
Phosphoprotein Phosphatases / pharmacology
Phosphorylation / drug effects
Receptors, Adrenergic, beta / physiology*
Receptors, N-Methyl-D-Aspartate / metabolism*
Synapses / metabolism*
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Calmodulin-Binding Proteins; 0/Receptors, Adrenergic, beta; 0/Receptors, N-Methyl-D-Aspartate; 60-92-4/Cyclic AMP; 66428-89-5/Forskolin; EC AMP-Dependent Protein Kinases; EC; EC Phosphatases

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