| Beta-adrenergic receptors: structure, function and regulation. | |
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MedLine Citation:
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PMID: 1974837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The diverse effects of the catecholamines (CA) epinephine and norepinephrine are mediated by a family of specific receptors (adrenergic receptors, AR). The beta-AR is a glycoprotein present in the membrane of a number of cell types. This receptor is closely associated with at least two other proteins (Gs and adenylate cyclase enzyme, AC) to form the beta-AR complex. The beta-AR recognizes the CA and is coupled to Gs which stimulates the effector enzyme AC. This enzyme converts ATP to cAMP and is the effector of the beta-AR complex. Thus the beta-AR is a G-coupled receptor which acts by raising intracellular levels of cAMP. The beta-AR is an important site of regulatory modifications through a variety of mechanisms. The best characterized is known as homologous desensitization: when the receptor is exposed to repeated stimulus by the agonist (CA), its responsiveness wanes, probably to compensate this potentially dangerous overstimulation. The gene for mammalian beta2-AR has been recently cloned and the predicted amino-acid sequence now opens the field to identification of the protein structures involved in receptor functions. The beta2-AR protein is characterized by the presence of seven membrane spanning regions. Study of the structure, function and regulation of the beta-AR will extend our knowledge of the role of beta-AR in pathological conditions and suggest new therapeutic approaches. |
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Authors:
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A De Blasi |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drugs under experimental and clinical research Volume: 16 ISSN: 0378-6501 ISO Abbreviation: Drugs Exp Clin Res Publication Date: 1990 |
Date Detail:
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Created Date: 1990-09-27 Completed Date: 1990-09-27 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7802135 Medline TA: Drugs Exp Clin Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 107-12 Citation Subset: IM |
Affiliation:
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Mario Negri Istituto di Ricerche Farmacologiche, Corsorzio Mario Negri Sud, Chieti, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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pharmacology Adrenergic beta-Antagonists / pharmacology Animals Humans Receptors, Adrenergic, beta / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic, beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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