Document Detail


Beta-adrenergic receptors and regulation of energy expenditure: a family affair.
MedLine Citation:
PMID:  14744248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The family of adrenergic receptors (ARs) expressed in adipocytes includes three sibling betaARs and two alphaAR cousins. Together they profoundly influence the mobilization of stored fatty acids, secretion of fat-cell derived hormones, and the specialized process of nonshivering thermogenesis in brown adipose tissue. The two types of fat cells that compose adipose tissue, brown and white, are structurally and functionally distinct. Studies on the mechanisms by which individual betaAR regulates these cell-specific functions have recently uncovered new signal transduction cascades involved in processes traditionally ascribed to adenylyl cyclase/cAMP/protein kinase A system. They illustrate how betaAR signaling can orchestrate a coordinated set of intracellular responses for fine control of metabolic balance.
Authors:
Jacques Robidoux; Tonya L Martin; Sheila Collins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annual review of pharmacology and toxicology     Volume:  44     ISSN:  0362-1642     ISO Abbreviation:  Annu. Rev. Pharmacol. Toxicol.     Publication Date:  2004  
Date Detail:
Created Date:  2004-01-27     Completed Date:  2004-05-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7607088     Medline TA:  Annu Rev Pharmacol Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297-323     Citation Subset:  IM    
Affiliation:
Departments of Pharmacology, Psychiatry, and Behavioral Sciences, and The Sarah W. Stedman Center for Nutritional Studies, Duke University Medical Center, Durham, North Carolina 27710, USA. robid001@mc.duke.edu
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / cytology,  metabolism*
Animals
Energy Metabolism / physiology*
Humans
Lipolysis
Obesity / metabolism
Receptors, Adrenergic, beta / physiology*
Signal Transduction*
Thermogenesis
Grant Support
ID/Acronym/Agency:
R01 DK57698/DK/NIDDK NIH HHS; R01DK46793/DK/NIDDK NIH HHS; R01DK53092/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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