Document Detail


Beta-adrenergic receptor genes are associated with arterial stiffness in black and white adults: the Bogalusa Heart Study.
MedLine Citation:
PMID:  18047913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sympathetic nervous activity, which is regulated by the beta-adrenergic receptor (beta-AR), is an important determinant of the arterial wall-stiffening process. This study examines the genetic influence of beta-AR gene polymorphisms (beta(1)-AR Arg389Gly, beta(2)-AR Arg16Gly, and beta(3)-AR Trp64Arg) on arterial stiffness in black and white young adults. METHODS: The study cohort included 366 black and 891 white adults, aged 19 to 44 years, enrolled in the Bogalusa Heart Study. Aorta-femoral pulse-wave velocity (af-PWV) was measured by echo-Doppler in a subsample (n = 614). RESULTS: Pulse pressure and heart rate were significantly associated with af-PWV in both races, but not with the three polymorphisms. The af-PWV values differed significantly among the beta(1)-AR Arg389Gly genotype groups in whites (P = .007) and in the total sample (P = .005), with those who were homozygous for Gly389 showing higher values than those who were homozygous for Arg389, after adjusting for cardiovascular risk factors. The beta(3)-AR Arg64 allele was associated with higher af-PWV values in blacks (P = .022) and in the total sample (P = .015). The beta(2)-AR Arg16 allele was associated with af-PWV only in blacks (P = .020). In multivariate regression analysis for the total sample, age, pulse pressure, heart rate, beta(1)-AR Arg389Gly, beta(3)-AR trp64Gly, and smoking status were, in descending order, associated with af-PWV. Furthermore, af-PWV values significantly increased with the increasing number of beta(1)-AR Gly389, beta(2)-AR Arg16, and beta(3)-AR Arg64 alleles (P for trend = .0003). CONCLUSIONS: These results indicate that the beta-AR gene polymorphisms influence arterial stiffness in black and white young adults in an additive manner.
Authors:
Wei Chen; Sathanur R Srinivasan; Eric Boerwinkle; Gerald S Berenson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  20     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-30     Completed Date:  2008-02-28     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1251-7     Citation Subset:  IM    
Affiliation:
Tulane Center for Cardiovascular Health, Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group / genetics
Aorta / physiology
Arteries / physiology*
Blood Pressure / genetics
Cohort Studies
Elasticity
European Continental Ancestry Group / genetics
Female
Femoral Artery / physiology
Gene Frequency
Heart Rate / genetics
Humans
Louisiana / epidemiology
Male
Polymorphism, Genetic*
Receptors, Adrenergic, beta / genetics*
Grant Support
ID/Acronym/Agency:
AG-16592/AG/NIA NIH HHS; HD-047247/HD/NICHD NIH HHS; HL-38844/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta

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