Document Detail

Beta-adrenergic blocker therapy does not worsen intermittent claudication in subjects with peripheral arterial disease. A meta-analysis of randomized controlled trials.
MedLine Citation:
PMID:  1679624     Owner:  NLM     Status:  MEDLINE    
Beta-Adrenergic blockers have been considered relatively contraindicated in peripheral arterial disease because of the perceived risk that these drugs could worsen intermittent claudication. Therefore, we conducted a meta-analysis of available randomized controlled trials from the English-language literature to determine whether or not beta-blockers exacerbate intermittent claudication. The primary focus of this analysis was the effect of beta-blockers on exercise duration, measured as walking capacity or endurance time. Outcomes were pooled where appropriate. Of 11 eligible reports, six included 11 individual controlled treatment comparisons that provided data for an analysis of pain-free exercise capacity; no effect size was statistically significant. The pooled effect size for pain-free walking distance was -0.24 (95% confidence interval, -0.62 to 0.14), indicating no significant impairment of walking capacity compared with placebo. Only one study reported that certain beta-blockers were associated with worsening of intermittent claudication. These results strongly suggest that beta-blockers do not adversely affect walking capacity or symptoms of intermittent claudication in patients with mild to moderate peripheral arterial disease. In the absence of other contraindications, beta-blockers can probably be used safely in such patients.
K Radack; C Deck
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Archives of internal medicine     Volume:  151     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-10-04     Completed Date:  1991-10-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1769-76     Citation Subset:  AIM; IM    
Department of Internal Medicine, University of Cincinati, College of Medicine, Ohio.
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MeSH Terms
Adrenergic beta-Antagonists / contraindications*,  therapeutic use
Exercise Test
Intermittent Claudication / chemically induced*,  physiopathology
Leg / blood supply
Meta-Analysis as Topic
Middle Aged
Physical Endurance / drug effects
Regional Blood Flow / drug effects
Reg. No./Substance:
0/Adrenergic beta-Antagonists
Comment In:
Arch Intern Med. 1991 Sep;151(9):1705-7   [PMID:  1679623 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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