| Beta-adrenergic blockade and metabo-chemoreflex contributions to exercise capacity. | |
| | |
MedLine Citation:
|
PMID: 18845967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Exercise-induced dyspnea in patients with cardiopulmonary diseases may be related to sympathetic nervous system activation, with increased metabo- and/or chemosensitivities. Whether this mechanism plays a role in exercising normal subjects remains unclear. METHODS: Muscle sympathetic nerve activity (MSNA), HR, ventilation (V(E)), O2 saturation (SpO2), and end-tidal PCO2 (PetCO2) were measured in 14 healthy young adults after 1 wk of beta1-receptor blockade with bisoprolol 5 mg x d(-1) versus placebo after a double-blind, placebo-controlled, randomized crossover design. The MSNA and the ventilatory responses to hyperoxic hypercapnia (7% CO2 in O2), DeltaV(E)/DeltaPetCO2, and isocapnic hypoxia (10% O2 in N2), DeltaV(E)/DeltaSpO2, and to an isometric muscle contraction followed by a local circulatory arrest (metaboreflex) were determined at rest followed by an incremental cardiopulmonary exercise test. RESULTS: Bisoprolol did not change the V(E) and MSNA responses to hypercapnia, hyperoxia, or isometric muscle contraction or ischemia. Bisoprolol decreased maximum O2 uptake (P < 0.05), workload (P < 0.05), and HR (P < 0.0001) and both V(E)/VO2 and V(E)/VCO2 slopes (P < 0.05). CONCLUSIONS: These results suggest that decreased aerobic exercise capacity after intake of beta-blockers is accompanied by decreased ventilation at any metabolic rate. However, this occurs without detectable change in the sympathetic nervous system tone or in metabo- or chemosensitivity and is therefore probably of hemodynamic origin. |
| | |
Authors:
|
Sofia Beloka; Marko Gujic; Gael Deboeck; Georges Niset; Agnieszka Ciarka; Jean-François Argacha; Dionysios Adamopoulos; Philippe Van de Borne; Robert Naeije |
Related Documents
:
|
3957827 - Oxygen delivery and utilization in hypothermic dogs. 16394687 - Effects of increasing concentrations of propofol on jugular venous bulb oxygen saturati... 1234887 - The prediction of maximal oxygen uptake before and after physical training in children. 8708577 - Design of the oxygen and substrate pathways. vii. different structural limits for oxyge... 426097 - Plasma volume and electrolyte shifts with heavy exercise in sitting and supine positions. 7677677 - The biochemistry and clinical application of urinary oestriol measurement during late p... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Medicine and science in sports and exercise Volume: 40 ISSN: 1530-0315 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2008 Nov |
Date Detail:
|
Created Date: 2009-05-12 Completed Date: 2009-07-06 Revised Date: 2009-07-13 |
Medline Journal Info:
|
Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
|
Languages: eng Pagination: 1932-8 Citation Subset: IM; S |
Affiliation:
|
Department of Cardiology, Erasme Hospital, Brussels, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adrenergic beta-Antagonists / pharmacology* Adult Cross-Over Studies Double-Blind Method Exercise / physiology* Hemodynamics / drug effects* Humans Male Muscle, Skeletal / drug effects*, metabolism Oxygen Consumption Placebos Sympathetic Nervous System / drug effects* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Placebos |
| Comments/Corrections | |
Comment In:
|
Med Sci Sports Exerc. 2009 Apr;41(4):967; author reply 968
[PMID:
19300143
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of exercise training intensity on abdominal visceral fat and body composition.
Next Document: Thermoregulatory responses to constant versus variable-intensity exercise in the heat.