| Beta-N-methylamino-L-alanine neurotoxicity: requirement for bicarbonate as a cofactor. | |
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MedLine Citation:
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PMID: 3136549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ingestion of the excitotoxic cycad seed amino acid beta-N-methylamino-L-alanine may be responsible for the neuronal degeneration associated with Guam amyotrophic lateral sclerosis-parkinsonism-dementia in man. However, the basis for the central neurotoxicity of beta-N-methylamino-L-alanine has been unclear, as it lacks the omega acidic (or equivalent electronegative) moiety characteristic of other excitatory amino acids. beta-N-methylamino-L-alanine produced neurotoxic and neuroexcitatory effects in murine cortical cell cultures only when physiological concentrations of bicarbonate were available in the extracellular bathing medium. Bicarbonate may interact noncovalently with beta-N-methylamino-L-alanine to produce, in combination, a molecular configuration that activates glutamate receptors. |
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Authors:
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J H Weiss; D W Choi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 241 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-09-19 Completed Date: 1988-09-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 973-5 Citation Subset: IM |
Affiliation:
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Department of Neurology, Stanford University Medical Center, Stanford 94305. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids, Diamino
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toxicity* Animals Bicarbonates / metabolism* Cells, Cultured Cerebral Cortex / drug effects* Electrophysiology Hydrogen-Ion Concentration Mice Microelectrodes Neurons / drug effects* Oxadiazoles / toxicity Quisqualic Acid beta-Alanine / analogs & derivatives, toxicity |
| Grant Support | |
ID/Acronym/Agency:
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NS12151/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Diamino; 0/Bicarbonates; 0/Oxadiazoles; 107-95-9/beta-Alanine; 16676-91-8/alpha-amino-beta-methylaminopropionate; 52809-07-1/Quisqualic Acid; 7554-90-7/oxalyldiaminopropionic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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