| Beta 2-receptor density on mononuclear blood cells in patients suffering from neuroleptic-induced akathisia (NIA). | |
| | |
MedLine Citation:
|
PMID: 8830953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effectiveness of beta-blockers in the treatment of neuroleptic-induced akathisia (NIA) suggests that beta-adrenergic overactivity is involved in the manifestation of NIA. As an approach to understanding this postulated overactivity, we investigated the beta 2-receptor density on mononuclear blood cells in 21 patients suffering from NIA as well as in 12 patients without NIA. The beta 2-receptor density in NIA-positive patients was significantly higher than that in NIA-negative patients (t = 2.84; p = .008). The NIA-positive patients were treated with 20 mg propranolol t.i.d. for 5 days. The beta 2-receptor density in treatment responders did not differ significantly from that in non-responders. Our results indicate that beta 2-receptors on mononuclear cells in patients with NIA may be of a certain degree of importance. With the prerequisites of replicability as well as correlation of this parameter with therapeutic success of beta-blockers, it may be considered as a predictor for treatment response. |
| | |
Authors:
|
C Botschev; B Bondy; M Hofmann; T Kircher; F Müller-Spahn |
Related Documents
:
|
2792473 - Transfusion malaria amongst operated neurosurgical patients--a prospective study of 22 ... 3860133 - Combined subcutaneous and high-dose intravenous deferoxamine therapy of thalassemia. 14977743 - Assessment based on euroscore of ministernotomy for aortic valve replacement. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biological psychiatry Volume: 40 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 1996 Aug |
Date Detail:
|
Created Date: 1996-12-04 Completed Date: 1996-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 203-7 Citation Subset: IM |
Affiliation:
|
Psychiatric Hospital of the Ludwig-Maximilians-University of Munich, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Akathisia, Drug-Induced / etiology* Antipsychotic Agents / adverse effects*, blood* Female Humans Male Middle Aged Propranolol / adverse effects*, blood* Receptors, Adrenergic, beta-2 / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Antipsychotic Agents; 0/Receptors, Adrenergic, beta-2; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Semantic matching of pictures in schizophrenia: a cross-cultural ERP study.
Next Document: The reliability of the diagnostic features in patients with narcolepsy.