Document Detail

Beta 2-receptor density on mononuclear blood cells in patients suffering from neuroleptic-induced akathisia (NIA).
MedLine Citation:
PMID:  8830953     Owner:  NLM     Status:  MEDLINE    
The effectiveness of beta-blockers in the treatment of neuroleptic-induced akathisia (NIA) suggests that beta-adrenergic overactivity is involved in the manifestation of NIA. As an approach to understanding this postulated overactivity, we investigated the beta 2-receptor density on mononuclear blood cells in 21 patients suffering from NIA as well as in 12 patients without NIA. The beta 2-receptor density in NIA-positive patients was significantly higher than that in NIA-negative patients (t = 2.84; p = .008). The NIA-positive patients were treated with 20 mg propranolol t.i.d. for 5 days. The beta 2-receptor density in treatment responders did not differ significantly from that in non-responders. Our results indicate that beta 2-receptors on mononuclear cells in patients with NIA may be of a certain degree of importance. With the prerequisites of replicability as well as correlation of this parameter with therapeutic success of beta-blockers, it may be considered as a predictor for treatment response.
C Botschev; B Bondy; M Hofmann; T Kircher; F Müller-Spahn
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychiatry     Volume:  40     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM    
Psychiatric Hospital of the Ludwig-Maximilians-University of Munich, Germany.
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MeSH Terms
Akathisia, Drug-Induced / etiology*
Antipsychotic Agents / adverse effects*,  blood*
Middle Aged
Propranolol / adverse effects*,  blood*
Receptors, Adrenergic, beta-2 / drug effects*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Receptors, Adrenergic, beta-2; 525-66-6/Propranolol

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