Document Detail

Beta-2-microglobulin in trophoblastic disease.
MedLine Citation:
PMID:  6191398     Owner:  NLM     Status:  MEDLINE    
Beta-2-microglobulin (BMG) is physically linked to the allo-antigenic HLA chain on the cell surface and is accordingly a marker for the HLA antigens. BMG concentrations were measured in serum and cerebrospinal fluid (CSF) samples from 22 patients with choriocarcinoma, 5 with hydatidiform mole and 17 reference subjects in the first trimester of pregnancy. Serum BMG levels were elevated in the patients with choriocarcinoma, particularly when human chorionic gonadotrophin levels were higher than 50 000 U/l (less than 50 000 U/l--1,6 +/- 0,3 mg/l; greater than 50 000 U/l--2,75 +/- 0,72 mg/l; molar pregnancy--1,42 +/- 0,44 mg/l; reference subjects--1,47 +/- 0,15 mg/l) (mean +/- 1 SD). BMG levels in the serum and CSF were not increased when metastases were present in the cranium. None of the patients had evidence of abnormal renal function as determined by serum urea, electrolyte and creatinine levels and the creatinine clearance rate. These results suggest that BMG and HLA antigens are expressed on the trophoblastic cells in choriocarcinoma, or alternatively that the maternal immunocytes produce increased quantities of BMG.
R J Norman; I Jialal; S M Joubert; R W Green-Thompson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  64     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  90-2     Citation Subset:  IM    
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MeSH Terms
Beta-Globulins / analysis*
Choriocarcinoma / blood*,  cerebrospinal fluid
Chorionic Gonadotropin / blood
Hydatidiform Mole / blood*,  cerebrospinal fluid
Uterine Neoplasms / blood*
beta 2-Microglobulin / analysis*,  cerebrospinal fluid
Reg. No./Substance:
0/Beta-Globulins; 0/Chorionic Gonadotropin; 0/beta 2-Microglobulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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