| Beta-2-microglobulin haplotypes in U.S. beef cattle and association with failure of passive transfer in newborn calves. | |
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MedLine Citation:
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PMID: 15014972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Failure of passive transfer (FPT) is a condition in which neonates do not acquire protective serum levels of maternal antibodies. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog ( FCGRT) and beta-2-microglobulin ( B2M). Previously, two FCGRT haplotypes were associated with differences in immunoglobulin G (IgG) passive transfer in cattle (Laegreid et al. (2002) Mamm Genome 13, 704-710). The present study had two objectives: first, to characterize the B2M haplotype structure in a diverse group of U.S. beef cattle, and second, to evaluate those haplotypes for association with either high or low serum IgG levels in newborn calves. Twelve single nucleotide polymorphisms (SNPs), assorted into eight haplotypes, were identified by sequencing regions of B2M exons II and IV in a multi-breed panel of 96 beef cattle. Calves homozygous for one of the eight haplotypes ( B2M 2,2) were at increased risk of FPT (odds ratio = 10.60, CI(95%) 2.07-54.24, p = 0.005). These results indicate that this haplotype is in linkage disequilibrium with genetic risk factors affecting passive transfer of IgG in beef calves, an important determinant of neonatal calf morbidity and mortality. |
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Authors:
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Michael L Clawson; Michael P Heaton; Carol G Chitko-McKown; James M Fox; Timothy P L Smith; Warren M Snelling; John W Keele; William W Laegreid |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Mammalian genome : official journal of the International Mammalian Genome Society Volume: 15 ISSN: 0938-8990 ISO Abbreviation: Mamm. Genome Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-11 Completed Date: 2004-10-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9100916 Medline TA: Mamm Genome Country: United States |
Other Details:
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Languages: eng Pagination: 227-36 Citation Subset: IM |
Affiliation:
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United States Department of Agriculture, Agricultural Research Service, U.S. Meat Animal Research Center (MARC), Spur 18D, P.O. Box 166, Clay Center, Nebraska 68933, USA. clawson@email.marc.usda.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Husbandry
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methods Animals Animals, Newborn / immunology* Base Sequence Cattle / genetics* Chromosome Mapping DNA Primers Genetic Variation* Genotype Haplotypes / genetics* Histocompatibility Antigens Class I Immunity, Maternally-Acquired Immunoglobulin G / blood* Linkage Disequilibrium Molecular Sequence Data Polymorphism, Single Nucleotide Receptors, Fc / genetics* Sequence Analysis, DNA Species Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization United States beta 2-Microglobulin / genetics* |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Fc receptor, neonatal; 0/Histocompatibility Antigens Class I; 0/Immunoglobulin G; 0/Receptors, Fc; 0/beta 2-Microglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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