| Beta-2-microglobulin-associated amyloidosis in chronic hemodialysis patients with carpal tunnel syndrome. | |
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MedLine Citation:
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PMID: 2646507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clinical manifestations of beta-2-microglobulin (beta 2M)-associated amyloidosis in chronic hemodialysis patients with carpal tunnel syndrome from a medical center hospital are presented. The predominant morbidity of beta 2M-amyloid was musculoskeletal, with deposits identified in surgical or biopsy specimens from trigger fingers, carpal tunnels, fractures, and radiolucent bone lesions. Lucent bone lesions were the characteristic radiologic finding of beta 2M-amyloidosis and were most commonly found in carpal bones, humeral heads, and femoral heads. Carpal tunnel syndrome occurred in greater than 20% of our chronic hemodialysis patients. The longer the period of time on chronic hemodialysis the greater the morbidity from beta 2M-amyloid. Although significant amounts of beta 2M-amyloid were detected in the perivascular regions of viscera, clinical compromise of internal organs from this type of amyloid was not documented. In acute studies, beta 2M clearance during hemodialysis was markedly increased using the Fresenius polysulfone dialyzers compared to cuprophane dialyzers. In summary, beta 2M-amyloid is common and causes significant morbidity in chronic hemodialysis patients. Long-term dialysis with highly permeable membranes effects greater beta 2M clearance which may result in less tissue deposition of beta 2M-amyloid, and therefore, fewer clinical complications. |
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Authors:
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M E Ullian; W S Hammond; A C Alfrey; A Schultz; B A Molitoris |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Medicine Volume: 68 ISSN: 0025-7974 ISO Abbreviation: Medicine (Baltimore) Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-04-14 Completed Date: 1989-04-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985248R Medline TA: Medicine (Baltimore) Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 107-15 Citation Subset: AIM; IM |
Affiliation:
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Division of Nephrology, Veterans Administration Medical Center, Denver, Colorado 80220. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amyloid
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analysis* Amyloidosis / etiology*, metabolism Bone Diseases / etiology Carpal Tunnel Syndrome / etiology*, metabolism Humans Male Middle Aged Muscular Diseases / etiology Renal Dialysis / adverse effects* Synovial Membrane / analysis beta 2-Microglobulin / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Amyloid; 0/beta 2-Microglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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