| Beta 2-microglobulin amyloidosis: a sternoclavicular joint biopsy study in hemodialysis patients. | |
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MedLine Citation:
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PMID: 2178825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of beta 2-microglobulin deposits appears to increase with time on dialysis. However, the precise prevalence of the disease is not known at present because adequate, noninvasive diagnostic procedures are still lacking. We performed systematic synovial biopsies of the sternoclavicular joint during surgical parathyroidectomy in 22 chronic hemodialysis patients with severe hyperparathyroidism. Nine of the patients proved to have beta 2-microglobulin amyloid deposits as demonstrated by Congo red staining and by immunofluorescence. They had undergone dialysis for longer time periods (12.6 vs 8.5 years, p less than 0.02) and tended to be older than the 13 amyloid-negative patients. They also had a significantly higher body aluminum overload, as demonstrated by a higher increase of plasma aluminum after desferrioxamine infusion. Finally, the presence of Congo-red-positive deposits correlated well with clinical and x-ray findings suggestive of dialysis amyloidosis. |
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Authors:
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J Zingraff; L H Noël; T Bardin; D Kuntz; C Dubost; T Drüeke |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nephrology Volume: 33 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-04-20 Completed Date: 1990-04-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 94-7 Citation Subset: IM |
Affiliation:
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Department of Nephrology, INSERM, Hôpital Necker, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amyloidosis
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etiology*,
metabolism Biopsy Female Humans Hyperparathyroidism, Secondary / etiology* Male Middle Aged Renal Dialysis / adverse effects* Sternoclavicular Joint / pathology* Synovial Membrane / pathology beta 2-Microglobulin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/beta 2-Microglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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