Document Detail

Beta 2-microglobulin amyloidosis (AB2M) in patients undergoing long-term hemodialysis. A new type of amyloid.
MedLine Citation:
PMID:  3307375     Owner:  NLM     Status:  MEDLINE    
Amyloidosis has been increasingly recognized in association with renal failure and chronic hemodialysis. This report describes three patients who had long-term hemodialysis (between 7-18 years), in whom deposits developed of a new type of amyloid of beta 2-microglobulin origin. Beta 2-microglobulin amyloid (AB2M) was found in multiple organs, i.e., bone, subendocardium, gastrointestinal blood vessels, tongue, and carpal tunnel connective tissue. AB2M displayed characteristic amyloid features on conventional light and polarized microscopic examination after congo red staining. However immunostaining with anti-amyloid A protein, kappa, and lambda antisera were negative. The studied material reacted positively with beta 2-microglobulin antisera, identifying AB2M in all three cases. Ultrastructural study revealed an unusual curvi-linear fibrillar configuration. AB2M appears to be a new subtype of systemic amyloidosis secondary to renal failure and long-term hemodialysis.
A Fuchs; J Jagirdar; I S Schwartz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  88     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-14     Completed Date:  1987-10-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  302-7     Citation Subset:  AIM; IM    
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MeSH Terms
Amyloidosis / etiology*,  metabolism,  pathology
Carpal Tunnel Syndrome / etiology,  metabolism
Duodenal Diseases / etiology
Femur / analysis,  pathology
Gastrointestinal Hemorrhage / etiology
Hypertension / complications
Middle Aged
Renal Dialysis / adverse effects*
Time Factors
Tongue / analysis,  pathology
beta 2-Microglobulin / analysis*
Reg. No./Substance:
0/beta 2-Microglobulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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