Document Detail


Beta 2-adrenergic agonist as adjunct therapy to levodopa in Parkinson's disease.
MedLine Citation:
PMID:  8058159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effect of the beta 2-adrenergic agonist albuterol on Parkinson's disease (PD) patients receiving chronic levodopa treatment. The albuterol-treated patients demonstrated reduced parkinsonian symptoms and an increased ability to tap their index finger between two points 20 cm apart, and were able to perform a "walk test" in 70% of their control time. Three patients currently on chronic albuterol therapy still show amelioration of their parkinsonian symptoms, and two have reduced their daily levodopa dose. This study suggests that beta 2-adrenergic agonists as adjunct therapy to levodopa may be beneficial in PD.
Authors:
G M Alexander; R J Schwartzman; T A Nukes; J R Grothusen; M D Hooker
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  44     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-09-12     Completed Date:  1994-09-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1511-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, Jefferson Medical College, Philadelphia, PA 19107.
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MeSH Terms
Descriptor/Qualifier:
Aged
Albuterol / therapeutic use*
Drug Therapy, Combination
Humans
Levodopa / therapeutic use*
Male
Middle Aged
Parkinson Disease / drug therapy*
Grant Support
ID/Acronym/Agency:
5 RO1 NS27101/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Levodopa; 18559-94-9/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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